Table 4 Antibiotic sensitivity of infants with ESBL-positive and ESBL-negative Escherichia coli invasive infection [% (n/N)]
Antibiotic | ESBL positive group (n = 35) | ESBL negative group (n = 87) | χ2 values | P | |
|---|---|---|---|---|---|
β-lactams | Ampicillin | 2.86 (1/35) | 36.78 (32/87) | 14.557 | 0.000 |
Piperacillin | 8.57 (3/35) | 35.63 (31/87) | 9.092 | 0.003 | |
Cefazolin | 11.43 (4/35) | 82.76 (72/87) | 54.066 | 0.000 | |
Ceftazidime | 80.00 (28/35) | 98.85 (86/87) | 11.561 | 0.001 | |
Cefotaxime | 37.14 (13/35) | 97.70 (85/87) | 57.924 | 0.000 | |
Cefepime | 34.29 (12/35) | 98.85 (86/87) | 65.842 | 0.000 | |
Compound preparations of β-lactam inhibitors | Amoxicillin/clavulanic acid | 57.14 (20/35) | 91.95 (80/87) | 20.463 | 0.000 |
Ampicillin/sulbactam | 40.00 (14/35) | 57.47 (50/87) | 3.055 | 0.080 | |
Cefoperazone/sulbactam | 97.14 (34/35) | 100.00 (87/87) | – | 0.287a | |
Piperacillin/tazobactam | 94.29 (33/35) | 100.00 (87/87) | – | 0.081a | |
Carbapenems | Imipenem | 100.00 (35/35) | 100.00 (87/87) | – | – |
Meropenem | 100.00 (35/35) | 100.00 (87/87) | – | – | |
Quinolones | Levofloxacin | 54.29 (19/35) | 73.56 (64/87) | 4.265 | 0.039 |
Ciprofloxacin | 48.57 (17/35) | 70.11 (61/87) | 5.024 | 0.025 | |
Aminoglycosides | Gentamicin | 60.00 (21/35) | 89.66 (78/87) | 14.348 | 0.000 |
Amikacin | 100.00 (35/35) | 100.00 (87/87) | – | – | |
Sulfonamides | Compound sulfamethoxazole | 28.57 (10/35) | 63.22 (55/87) | 12.036 | 0.001 |
Other antibiotics | Aztreonam | 65.71 (23/35) | 98.85 (86/87) | 25.411 | 0.000 |