Phenotypic and genotypic drug sensitivity profiles of Mycobacterium tuberculosis infection and associated factors in northeastern Ethiopia

Table 2 Performance of GenoTypic MTBDRplus assay for detection of RIF, INH and MDR resistance in comparison to phenotypic BACTEC MGIT 960 System

Drugs	MTBDRplus	BACTEC MGIT 960		Sensitivity(%)	Specificity(%)	PPV(%)	NPV(%)	Kappa
Drugs	MTBDRplus	Resistant	Sensitive	Sensitivity(%)	Specificity(%)	PPV(%)	NPV(%)	Kappa
RIF	Resistant	7	1	100	98.3	87.5	100	0.925 (p < 0.001)
RIF	Sensitive	0	57	100	98.3	87.5	100	0.925 (p < 0.001)
INH	Resistant	6	1	75	98.2	85.7	96.6	0.774 (p < 0.001)
INH	Sensitive	2	56	75	98.2	85.7	96.6	0.774 (p < 0.001)
MDR	Resistant	5	0	83.3	100	100	98.3	0.901 (p < 0.001)
MDR	Sensitive	1	59	83.3	100	100	98.3	0.901 (p < 0.001)

ISSN: 1471-2334