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Table 1 Clinical characteristics of patients from whom carbapenemase-producing Enterobacterales strains were isolated

From: Institutional outbreak involving multiple clades of IMP-producing Enterobacter cloacae complex sequence type 78 at a cancer center in Tokyo, Japan

Characteristics All patients
(n = 18)
Patients with isolation of ECC ST78 (n = 14) Patients with isolation of ECC non-ST78 (n = 4)
Age, mean y [SD] 68.8 [8.1] 69.1 [7.7] 67.8 [9.0]
 Age > 65y 12 (66.7) 9 (64.3) 3 (75)
Sex
 Male 16 (88.9) 13 (92.9) 3 (75)
 Female 2 (11.1) 1 (7.1) 1 (25)
Status
 Infection 6 (33.3) 5 (35.7) 1 (25)
 Colonization detected by clinical cultures 7 (38.9) 4 (28.6) 3 (75)
 Colonization detected by surveillance cultures 5 (27.8) 5 (35.7) 0 (0)
Sample from which CPE was first isolated
 Sputum 6 (33.3) 5 (35.7) 1 (25)
 Bile 3 (16.7) 0 (0) 3 (75)
 Stool 3 (16.7) 3 (21.4) 0 (0)
 Intraabdominal fluid 2 (11.1) 2 (14.3) 0 (0)
 Other 4 (22.2) 4 (28.6) 0 (0)
Ward at the time of isolation of CPE
 ICU 6 (33.3) 4 (28.6) 2 (50)
 Ward-V 5 (27.8) 5 (35.7) 0 (0)
 Ward-X 3 (16.7) 3 (21.4) 0 (0)
 Other 4 (22.2) 2 (14.3) 2 (50)
Department at the time of isolation of CPE
 Surgery-A 7 (38.9) 5 (35.7) 2 (50)
 Surgery-B 4 (22.2) 4 (28.6) 0 (0)
 Medical Oncology-E 3 (16.7) 3 (21.4) 0 (0)
 Other 4 (22.2) 2 (14.3) 2 (50)
Type of malignancy
 Gastrointestinal 17 (94.4) 14 (100) 3 (75)
 Thoracic 1 (5.6) 0 (0) 1 (25)
Cancer chemotherapy within 90 days 6 (33.3) 6 (42.9) 0 (0)
Antimicrobial use within 30 days 16 (88.9) 13 (92.9) 3 (75)
Surgery within 30 days 14 (77.8) 10 (71.4) 4 (100)
 Gastrointestinal 13 (72.2) 10 (71.4) 3 (75)
 Thoracic 1 (5.6) 0 (0) 1 (25)
Endoscopic procedure within 90 daysa 15 (83.3) 12 (85.7) 3 (75)
 Laryngoscopy 3 (16.7) 3 (21.4) 0 (0)
 Esophagogastroscopy 13 (72.2) 11 (78.6) 2 (50)
 Duodenoscopy with ERCP 4 (22.2) 2 (14.3) 2 (50)
 Colonoscopy 6 (33.3) 5 (35.7) 1 (25)
 Bronchoscopy 2 (11.1) 2 (14.3) 0 (0)
30-day mortality 1 (5.6) 1 (7.1) 0 (0)
90-day mortality 3 (16.7) 2 (14.3) 1 (25)
  1. Data are mean [SD] or n (%)
  2. a If a patient received multiple endoscopic procedure, all were counted separately
  3. ECC Enterobacter cloacae complex, CPE carbapenemase-producing Enterobacterales, ERCP endoscopic retrograde cholangiopancreatography
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