|
Age, mean (SD)
|
60.8 (11.7)
|
67.4 (10.8)
|
64.7 (11.2)
|
63.4 (9.6)
|
63.8 (11.3)
|
67.4 (10.8)
|
65.0 (11.1)
|
64.55 (11.5)
|
|
Age categories, n (%)
|
|
18–30 years
|
123 (0.4)
|
28 (0.1)
|
34 (0.2)
|
28 (0.2)
|
23 (0.2)
|
28 (0.1)
|
14 (0.1)
|
26 (0.2)
|
|
30–40 years
|
875 (2.8)
|
309 (1.1)
|
213 (1.1)
|
308 (1.6)
|
206 (1.5)
|
309 (1.1)
|
118 (1.1)
|
238 (2.2)
|
|
40–50 years
|
4466 (14.3)
|
1302 (4.7)
|
1445 (7.7)
|
1297 (6.9)
|
1298 (9.7)
|
1302 (4.7)
|
834 (7.9)
|
865 (8.1)
|
|
50–60 years
|
10,214 (32.7)
|
4836 (17.6)
|
5018 (26. 6)
|
4694 (24.8)
|
3556 (26.6)
|
4836 (17.6)
|
2623 (24.7)
|
2472 (23.3)
|
|
60–70 years
|
8448 (27.1)
|
9521 (34.6)
|
5879 (31. 1)
|
7969 (42.2)
|
4157 (31.1)
|
9521 (34.6)
|
3388 (31.9)
|
3497 (32.9)
|
|
70–80 years
|
5380 (17.3)
|
8376 (30.5)
|
4666 (24.7)
|
3974 (21.0)
|
3097 (23.2)
|
8376 (30.5)
|
2703 (25.4)
|
2617 (24.6)
|
|
> 80 years
|
1688 (5.4)
|
3128 (11.4)
|
1640 (8.7)
|
625 (3.3)
|
1040 (7.8)
|
3128 (11.4)
|
943 (8.9)
|
908 (8.6)
|
|
Sex (Male), n (%)
|
15,213 (48.8)
|
12,547 (45.6)
|
8870 (46.9)
|
9243 (48.9)
|
5379 (40.2)
|
12,547 (45.6)
|
4628 (43.6)
|
4463 (42.0)
|
|
Smoker categories, n (%)
|
|
Non Smoker
|
17,968 (57.6)
|
15,514 (56.4)
|
10,725 (56.8)
|
10,668 (56.5)
|
8390 (62.7)
|
15,514 (56.4)
|
6384 (60.1)
|
6473 (60.9)
|
|
Ex-Smoker
|
9073 (29.1)
|
8329 (30.3)
|
5677 (30.0)
|
5700 (30.2)
|
3865 (28.9)
|
8329 (30.3)
|
3186 (30.0)
|
3137 (29.5)
|
|
Smoker
|
3962 (12.7)
|
3483 (12.7)
|
2402 (12.7)
|
2431 (12.9)
|
1058 (7.9)
|
3483 (12.7)
|
1005 (9.5)
|
967 (9.1)
|
|
Missing
|
191 (0.6)
|
174 (0.6)
|
91 (0.5)
|
96 (0.5)
|
64 (0.5)
|
174 (0.6)
|
48 (0.5)
|
46 (0.4)
|
|
Drinker Categories, n (%)
|
|
Non-drinker
|
4716 (15.1)
|
4186 (15.2)
|
2874 (15.2)
|
2856 (15.1)
|
2013 (15.1)
|
4186 (15.2)
|
1587 (14.9)
|
1508 (14.2)
|
|
Drinker without excess
|
11,716 (37.6)
|
10,281 (37.4)
|
7082 (37.5)
|
7134 (37.8)
|
5157 (38.6)
|
10,281 (37.4)
|
4023 (37.9)
|
3976 (37.4)
|
|
Excessive Drinker
|
7614 (24.4)
|
6238 (22.7)
|
4464 (23.6)
|
4673 (24.7)
|
2908 (21.7)
|
6238 (22.7)
|
2414 (22.7)
|
2368 (22.3)
|
|
Missing
|
7148 (22.9)
|
6795 (24.7)
|
4475 (23.7)
|
4232 (22.4)
|
3299 (24.7)
|
6795 (24.7)
|
2599 (24.5)
|
2771 (26.1)
|
|
BMI, mean (SD)
|
30.3 (6.4)
|
28.44 (5.6)
|
29.36 (6.0)
|
29.48 (5.7)
|
30.37 (6.2)
|
28.44 (5.6)
|
29.58 (5.9)
|
29.65 (5.9)
|
|
BMI Categories, n (%)
|
|
Underweight (< 18.5)
|
173 (0.6)
|
343 (1.3)
|
151 (0.8)
|
105 (0. 6)
|
67 (0.5)
|
343 (1.3)
|
65 (0.6)
|
62 (0.6)
|
|
Underweight (< 25)
|
5597 (17.9)
|
6898 (25.1)
|
4059 (21.5)
|
3645 (19.3)
|
2243 (16.8)
|
6898 (25.1)
|
2074 (19.5)
|
2033 (19.1)
|
|
Overweight (25–30)
|
10,948 (35.1)
|
10,536 (38.3)
|
7156 (37.9)
|
7171 (38.0)
|
4718 (35.3)
|
10,536 (38.3)
|
4055 (38.2)
|
3894 (36.7)
|
|
Obese (> 30)
|
13,300 (42.6)
|
8470 (30.8)
|
6771 (35.8)
|
7271 (38.5)
|
5854 (43.8)
|
8470 (30.8)
|
4004 (37.7)
|
4185 (39.4)
|
|
Missing
|
1176 (3.8)
|
1253 (4.6)
|
758 (4.0)
|
703 (3.7)
|
495 (3.7)
|
1253 (4.6)
|
425 (4.0)
|
449 (4.2)
|
|
Hypertension duration, mean years (SD)
|
9.8 (7.4)
|
8.6 (7.5)
|
9.4 (6.9)
|
9.4 (8.0)
|
11.4 (7.5)
|
8.6 (7.5)
|
10.5 (7.0)
|
11.3 (8.3)
|
|
Age at hypertension diagnosis, mean (SD)
|
51.0 (10.9)
|
58.8 (11.2)
|
55.3 (10.4)
|
54.0 (9.1)
|
52.4 (10.9)
|
58.8 (11.2)
|
54.5 (10.4)
|
53.2 (11.0)
|
|
Systolic BP, mean (SD)
|
135.9 (13.8)
|
137.3 (13.6)
|
136.7 (14.0)
|
136.4 (13.1)
|
136.3 (13.6)
|
137.3 (13.6)
|
136.8 (13.6)
|
136.6 (13.4)
|
|
Diastolic BP, mean (SD)
|
81.7 (9.4)
|
79.76 (9.3)
|
80.6 (9.3)
|
81.09 (9.0)
|
80.8 (9.1)
|
79.8 (9.3)
|
80.5 (9.2)
|
80.5 (9.3)
|
|
Missing, n (%)
|
80 (0.3)
|
63 (0.2)
|
0 (0%)
|
0 (0%)
|
22 (0.2)
|
63 (0.2)
|
0 (0%)
|
0 (0%)
|
|
Cholesterol, mean (SD)
|
5.13 (1.03)
|
5.13 (1.04)
|
5.12 (1.04)
|
5.13 (1.04)
|
5.13 (1.01)
|
5.13 (1.04)
|
5.14 (1.02)
|
5.13 (1.03)
|
|
Cholesterol Categories, n (%)
|
|
< 5.2 mmol/L
|
17,051 (54.7)
|
14,915 (54.2)
|
10,430 (55.2)
|
10,394 (55.0)
|
7415 (55.4)
|
14,915 (54.2)
|
5820 (54.8)
|
5894 (55.5)
|
|
5.2–6.2 mmol/L
|
8852 (28.4)
|
7712 (28.0)
|
5262 (27.9)
|
5323 (28.2)
|
3836 (28.7)
|
7712 (28.0)
|
3026 (28.5)
|
2929 (27.6)
|
|
> = 6.2 mmol/L
|
4153 (13.3)
|
3747 (13.6)
|
2543 (13.5)
|
2580 (13.7)
|
1699 (12.7)
|
3747 (13.6)
|
1419 (13.4)
|
1404 (13.2)
|
|
Missing
|
1138 (3.7)
|
1126 (4.1)
|
660 (3.5)
|
598 (3.2)
|
427 (3.2)
|
1126 (4.1)
|
358 (3.4)
|
396 (3.7)
|
|
HDL, mean (SD)
|
1.44 (0.43)
|
1.54 (0.46)
|
1.49 (0.44)
|
1.48 (0.44)
|
1.48 (0.43)
|
1.54 (0.46)
|
1.50 (0.44)
|
1.50 (0.45)
|
|
HDL categories, n (%)
|
|
< 1.55 mmol/L
|
19,720 (63.2)
|
14,873 (54.1)
|
10,949 (58.0)
|
11,464 (60. 7)
|
8160 (61.0)
|
14,873 (54.1)
|
6214 (58.5)
|
6251 (58.8)
|
|
> = 1.55 mmol/L
|
9851 (31.6)
|
11,114 (40.4)
|
7007 (37.1)
|
6566 (34.8)
|
4621 (34.5)
|
11,114 (40.4)
|
3915 (36.9)
|
3818 (35.9)
|
|
Missing
|
1623 (5.20)
|
1513 (5.5)
|
939 (5.0)
|
865 (4.6)
|
596 (4.5)
|
1513 (5.5)
|
494 (4.7)
|
554 (5.2)
|
|
eGFR, mean (SD)
|
86.1 (14.7)
|
82.8 (13.8)
|
83.33 (14.3)
|
85.08 (14.0)
|
82.9 (14.6)
|
82.8 (13.8)
|
82.36 (14.2)
|
83.89 (14.7)
|
|
eGFR category, n (%)
|
|
> 60 (Stage 2 and above)
|
29,735 (95.3)
|
25,680 (93.4)
|
17,806 (94.2)
|
17,924 (94.9)
|
12,538 (93.7)
|
25,680 (93.4)
|
9981 (94.0)
|
9927 (93.5)
|
|
30–59(Stage 3)
|
1127 (3.6)
|
1270 (4.6)
|
847 (4.5)
|
792 (4.2)
|
713 (5.3)
|
1270 (4.6)
|
530 (5.0)
|
578 (5.4)
|
|
Missing
|
332 (1.1)
|
550 (2.0)
|
242 (1.3)
|
179 (1.0)
|
126 (0.9)
|
550 (2.0)
|
112 (1.1)
|
118 (1.1)
|
|
Baseline conditions, n (%)
|
|
Atrial fibrillation
|
726 (2.3)
|
743 (2.7)
|
503 (2.7)
|
502 (2.7)
|
384 (2.9)
|
743 (2.7)
|
318 (3.0)
|
332 (3.1)
|
|
Rheumatoid arthritis
|
460 (1.5)
|
497 (1.8)
|
329 (1.7)
|
297 (1.6)
|
199 (1.5)
|
497 (1.8)
|
161 (1.5)
|
166 (1. 6)
|
|
Cancer
|
2525 (8.1)
|
3320 (12.1)
|
1921 (10.2)
|
1711 (9.1)
|
1377 (10.3)
|
3320 (12.1)
|
1151 (10.8)
|
1139 (10.7)
|
|
Respiratory Disease
|
1325 (4.3)
|
1695 (6.2)
|
1010 (5.4)
|
933 (4.9)
|
664 (5.0)
|
1695 (6.2)
|
586 (5.5)
|
572 (5.4)
|
|
Immunosuppresseda
|
571 (1.8)
|
616 (2.2)
|
392 (2.1)
|
358 (1.9)
|
239 (1.8)
|
616 (2.2)
|
205 (1.9)
|
198 (1.9)
|
|
Rare metabolic disorder
|
29 (0.1)
|
38 (0.1)
|
23 (0.1)
|
18 (0.1)
|
18 (0.1)
|
38 (0.1)
|
15 (0.1)
|
13 (0.1)
|
|
Other medications at baseline, n (%)
|
|
Previous prescription of ACE-I
|
31,194 (100)
|
6030 (21.9)
|
18,895 (100)
|
4462 (23.6)
|
8421 (63.0)
|
6030 (21.9)
|
5686 (53.5)
|
5638 (53.1)
|
|
Previous prescription of ARB
|
1036 (3.3)
|
1907 (6.9)
|
937 (5.0)
|
762 (4.0)
|
13,377 (100)
|
1907 (6.9)
|
10,623 (100)
|
1492 (14.0)
|
|
Previous prescription of CCB
|
8242 (26.4)
|
27,500 (100)
|
5554 (29.4)
|
18,895 (100)
|
5393 (40.3)
|
27,500 (100)
|
4001 (37.7)
|
10,623 (100)
|
|
Thiazide diuretics
|
5775 (18.5)
|
3919 (14.3)
|
5775 (18.5)
|
3919 (14.3)
|
3457 (25.8)
|
3919 (14.3)
|
2074 (19.5)
|
2468 (23.2)
|
|
Loop diuretics
|
768 (2.5)
|
461 (1.7)
|
768 (2.5)
|
461 (1.7)
|
417 (3.1)
|
461 (1.7)
|
331 (3.1)
|
219 (2.1)
|
|
Potassium diuretics
|
148 (0.5)
|
101 (0.4)
|
148 (0.5)
|
101 (0.4)
|
85 (0.6)
|
101 (0.4)
|
59 (0.6)
|
69 (0.7)
|
|
Alpha blockers
|
1017 (3.3)
|
659 (2.4)
|
1017 (3.3)
|
659 (2.4)
|
661 (4.9)
|
659 (2.4)
|
430 (4.1)
|
481 (4.5)
|
|
Beta blockers
|
3525 (11.3)
|
3030 (11.0)
|
3525 (11.3)
|
3030 (11.0)
|
1630 (12.2)
|
3030 (11.0)
|
1302 (12.3)
|
1423 (13.4)
|
|
Other antihypertensive
|
122 (0.4)
|
84 (0.3)
|
122 (0.4)
|
84 (0.3)
|
71 (0.5)
|
84 (0.3)
|
48 (0. 5)
|
48 (0.5)
|
|
Anticoagulants
|
884 (2.8)
|
889 (3.2)
|
884 (2.8)
|
889 (3.2)
|
446 (3.3)
|
889 (3.2)
|
370 (3.5)
|
385 (3.6)
|
|
Statins
|
9399 (30.1)
|
9133 (33.2)
|
9399 (30.1)
|
9133 (33.2)
|
3977 (29.7)
|
9133 (33.2)
|
3293 (31.0)
|
3230 (30.4)
|
