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Table 3 Antimicrobial usage by SARS-COV-2 and testing status

From: A multicenter analysis of the clinical microbiology and antimicrobial usage in hospitalized patients in the US with or without COVID-19

Antimicrobial

n (% of total antimicrobials)

Not tested for SARS-CoV-2

(n = 452,024)

Tested for SARS-CoV-2

SARS-CoV-2 negative

(n = 124,927)

SARS-CoV-2 positive

(n = 17,049)

Total number of antimicrobialsa

225,692 (100%)

133,735 (100%)

31,981 (100%)

Antibacterial

211,088 (93.5%)

125,811 (94.1%)

29,828 (93.3%)

 Cephalosporin

61,468 (27.2%)

37,514 (28.1%)

9142 (28.6%)

  Ceftriaxone

32,198 (14.3%)

20,081 (15.0%)

5864 (18.3%)

  Cefepime

13,201 (5.8%)

10,463 (7.8%)

2647 (8.3%)

 Macrolides

14,200 (6.3%)

12,883 (9.6%)

7482 (23.4%)

  Azithromycin

13,632 (6.0%)

12,642 (9.5%)

7461 (23.4%)

 Glycopeptides

37,961 (16.8%)

23,586 (17.6%)

4254 (13.3%)

  Vancomycin

37,955 (16.8%)

23,585 (17.6%)

4254 (13.3%)

 Beta-lactam/beta-lactamase inhibitors

31,642 (14.0%)

17,997 (13.5%)

3065 (9.6%)

  Piperacillin/tazobactam

24,729 (11.0%)

14,145 (10.6%)

1981 (6.2%)

 Tetracyclines

6668 (3.0%)

5585 (4.2%)

2038 (6.4%)

 Carbapenems

7684 (3.4%)

5068 (3.8%)

1145 (3.6%)

 Fluoroquinolones

14,171 (6.3%)

7119 (5.3%)

800 (2.5%)

Antivirals

8055 (3.6%)

3918 (2.9%)

1574 (4.9%)

 Neuraminidase inhibitors

2748 (1.2%)

823 (0.6%)

950 (3.0%)

Antifungals

6549 (2.9%)

4006 (3.0%)

579 (1.8%)

  1. aPatients could have more than one prescribed antibiotic