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Table 1 Univariate statistics and multivariate logistic regression analysis of patients’ characteristics and laboratory findings on admission

From: The clinical profiles and outcomes of HIV-negative cryptococcal meningitis patients in type II diabetes mellitus

Characteristics

Univariate analysis

Multivariate analysis

DM II group (n = 26)

Non-DM II group (n = 52)

P value

(95% CI)

P value

Age (years)

57.31 ± 14.27

52.20 ± 15.84

0.173

  

Sex: Male (n %)

12(46.15%)

29(55.77%)

0.423

  

Rural area (n %)

21(80.77%)

44(84.61%)

0.667

  

Underlying conditions

 Respiratory diseases (n %)

3(11.53%)

7(13.46%)

0.811

  

 Chronic kidney diseases (n %)

2(7.69%)

4(7.69%)

1.000

  

 Hepatitis B (n %)

3(11.53%)

3(5.77%)

0.367

  

 Hypertension (n %)

4(15.38%)

2(3.85%)

0.071

(0.026,1.109)

0.064

 Autoimmune disease (n %)

3(11.53%)

4(7.69%)

0.575

  

 Hematology and oncology (n %)

0

1(1.92%)

0.477

  

 The duration before confirmed diagnosis (days)

27.00 ± 23.13

26.30 ± 18.93

0.501

  

 Duration of DM II course (years)

4.20 ± 3.34

–

–

  

Clinical parameters

 Fever (n %)

21(80.77%)

39(75.00%)

0.569

  

 Headache (n %)

25(96.15%)

50(96.15%)

1.000

  

 Nausea/Vomiting (n %)

16(61.54%)

25(48.07%)

0.262

  

 Vision disorders (n %)

8(28.54%)

6(11.54%)

0.038*

(0.056,0.705)

0.012*

 Auditory symptoms (n %)

2(7.69%)

4(7.69%)

1.000

  

 Seizure (n %)

3(11.54%)

3(5.77%)

0.367

  

 Conscious disturbance (n %)

8(30.77%)

9(17.31%)

0.175

  

CSF examinations

 Opening pressure (mmH2O)

271.54 ± 100.78

234.23 ± 105.98

0.125

  

 CSF protein (mg/l)

1027.62 ± 594.16

705.72 ± 373.88

0.031*

(1.000,1.002)

0.016*

 CSF glucose (mmol/l)

2.08 ± 1.01

2.30 ± 1.41

0.250

  

 Positive India ink stain (n %)

19(73.08%)

40(76.92%)

0.709

  

 Positive cryptococcal antigen (n %)

25(96.15%)

50(96.13%)

1.000

  

 Positive culture result (n %)

17(65.38%)

32(61.54%)

0.740

  

Brain images (CT or MRI)

 Meningeal enhancement (n %)

10(38.46%)

22(42.30%)

0.745

  

 Hydrocephalus (n %)

2(7.69%)

4(7.69%)

1.000

  

 Cerebral infarction (n %)

4(15.38%)

6(11.54%)

0.632

  

 Abscess (n %)

2(7.69%)

2(3.84%)

0.468

  

 Normalea (n %)

8(30.77%)

18(34.62%)

0.734

  
  1. DM II diabetes mellitus II, CSF cerebrospinal fluid, CT computed tomography, MRI magnetic resonance imaging, CI confidence interval
  2. aNormal brain images on CT or MRI were defined as no obvious intracranial lesions demonstrated; *p < 0.05