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Table 1 Demographic and clinical characteristics of the general population and of patients experiencing or not experiencing CV events during hospitalisation for CAP

From: Acute cardiovascular events in patients with community acquired pneumonia: results from the observational prospective FADOI-ICECAP study

  General population
N = 1266
(100%)
Cardiovascular events P value
Yes
301 (23.8%)
No
965 (76.2%)
Demographic Characteristics
 Age mean (± SD) 76.2 ± 13.8 81.2 ± 9.2 74.6 ± 14.7 0.0001
 Age median (IQR) 79 (71–86) 83 (76–88) 78 (69–85) 0.0001
 Age ≥ 75 years 825 (65.2%) 240 (79.7%) 585 (60.6%) < 0.0001
 Female sex 615 (48.6%) 168 (55.8%) 447 (46.3%) 0.004
 Nursing home resident 61 (4.8%) 15 (5.0%) 46 (4.8%) 0.878
Cardiovascular Risk Factors and Diseases
 Current smoker 494 (39%) 108 (35.9%) 386 (40.0%) 0.062
 Former smoker 192 (15.2%) 34 (11.3%) 158 (16.4%) 0.058
 Peripheral arterial disease 82 (6.5%) 25 (8.3%) 57 (5.9%) 0.142
 COPD 347 (27.4%) 84 (27.9%) 263 (27.3%) 0.825
 Coronary artery disease 212 (16.7%) 73 (24.3%) 139 (14.4%) < 0.0001
 Ischemic stroke/TIA 132 (10.4%) 41 (13.6%) 91 (9.4%) 0.056
 Haemorrhagic stroke 20 (1.6%) 5 (1.7%) 15 (1.6%) 1
 Diabetes mellitus 300 (23.7%) 76 (25.2%) 224 (23.2%) 0.437
 Dyslipidemia 156 (12.3%) 35 (11.6%) 121 (12.5%) 0.763
 Venous thromboembolism 26 (2.1%) 2 (0.7%) 24 (2.5%) 0.061
 Chronic liver insufficiency 20 (1.6%) 6 (2.0%) 14 (1.5%) 0.595
 History of paroxysmal or permanent Atrial fibrillation/Flutter 257 (20.3%) 87 (28.9%) 170 (17.6%) < 0.0001
 Hypertension 694 (54.8%) 209 (69.4%) 485 (50.3%) < 0.0001
 CKD (GFR < 60 ml/min) 162 (12.8%) 47 (15.6%) 115 (11.9%) 0.113
 Cancer 207 (16.4%) 49 (16.3%) 158 (16.4%) 1
 Obesity 74 (5.8%) 20 (6.6%) 54 (5.6%) 0.484
 Chronic heart failure 269 (21.3%) 82 (27.2%) 187 (19.4%) 0.005
 Dementia 195 (15.4%) 47 (15.6%) 148 (15.3%) 0.927
 > 3 comorbidities 246 (19.4%) 80 (26.6%) 166 (17.2%) 0.0001
In-hospital and 30-day Outcome
 Length of stay median days (IQR) 9 (6–12) 10 (7–13) 8 (6–11) 0.0001
 In-hospital mortality 78 (6.2%) 34 (12.2%) 44 (4.7%) < 0.0001
 30-day mortality 135 (10.7%) 49 (16.3%) 86 (8.9%) 0.0001
 30-day re-hospitalisation 133 (10.5%) 40 (13.3%) 90 (9.3%) 0.002
Selected Cardiovascular drugs
 ACE-i/ARBs 553 (43.7%) 150 (49.8%) 403 (41.8%) 0.016
 Statins 289 (22.8%) 68 (22.6%) 221 (22.9%) 0.937
 Beta-blockers 398 (31.4%) 138 (45.8%) 260 (26.9%) < 0.0001
 Calcium channel blockers 229 (18.1%) 50 (16.6%) 179 (18.5%) 0.493
 Diuretics 545 (43%) 149 (49.5%) 396 (41.0%) 0.011
 Anticoagulants 195 (15.4%) 55 (18.3%) 140 (14.5%) 0.12
 Antiplatelets 455 (35.9%) 141 (46.8%) 314 (32.5%) < 0.0001
  1. COPD Chronic obstructive pulmonary disease, CKD Chronic kidney disease, GFR Glomerular filtration rate, ACE-i Angiotensin converting enzyme inhibitors, ARBs Angiotensin receptor blockers
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