Skip to main content

Table 4 Allele and genotype frequencies of TNF-α -308G/A, -238G/A, -376G/A and +489G/A SNPs according to outcome in the study group

From: Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression

 Survivors
n (%)
60 (42.9%)
Deceased
n (%)
103 (57.1%)
Total
n (%)
163
P value;
OR (95% CI)
TNF-α -308G/A
 AA1 (1.7%)1 (1.0%)2 (1.2%)0.88; 1.90 (0.11–31.26)
 AG16 (26.7%)20 (19.4%)36 (22.1%)0.32; 1.52 (0.71–3.24)
 GG43 (71.7%)82 (79.6%)125 (76.7%)Reference
 AA+AG17 (28.3%)21 (20.4%)38 (23.3%)0.25; 1.54 (0.73–3.23)
TNF-α -238G/A
 AG3 (5.0%)3 (4.9%)8 (4.9%)0.67; 1.71 (0.33–8.80)
 GG57 (95.0%)98 (95.1%)155 (95.1%)Reference
TNF-α -376G/A
 AG0 (0.0%)4 (3.9%)4 (2.5%)0.29; 0.18 (0.009–3.45)
 GG60 (100.0%)99 (96.1%)159 (97.5%)Reference
TNF-α +489 G/A
 AA2 (3.3%)1 (1.0%)3 (1.8%)0.56; 3.15 (0.27–35.84)
 AG13 (21.7%)31 (30.1%)44 (27%)0.35; 0.66 (0.31–1.39)
 GG45 (75.0%)71 (68.9%)116 (71.2%)Reference
 AA+AG15 (25.0%)32 (31.1%)47 (28.8%)0.47; 0.74 (0.36–1.51)