Table 1 Epidemiology and history of MRSA vs. MSSA endocarditis (bivariate analysis)
MSSA IE N = 378 | MRSA IE N = 59 | p* | |
|---|---|---|---|
Mean age (yrs), (± DS) | 58.05. (±17.8) | 62.3. (±15) | 0.048 |
Females, n (%) | 133 (35.2) | 21 (35.6) | 0.95 |
Males | 245 (64.8) | 38 (64.4) | |
Native IE, n (%) | 295 (78) | 44 (74.6) | 0.55 |
Early prosthetic IE, n (%) | 20 (5.3) | 7 (11.9) | 0.07 |
Late prosthetic IE, n (%) | 39 (10.3) | 4 (6.7) | 0.39 |
IE on device (AICD, PMK), n (%) | 34 (8.9) | 5 (8.4) | 0.89 |
Valve involved, n (%) | |||
- Mitral | 209 (55.3) | 31 (52.5) | 0.8 |
- Aortic | 129 (34.1) | 16 (27.1) | 0.34 |
- Mitro-aortic | 17 (4.2) | 4 | 0.5 |
- Mitral, aortic, and tricuspid | 3 (0.8) | 0 | 1 |
- Mitral and tricuspid or Aortic and tricuspid | 16 (4.2) | 1 (1.7) | 0.7 |
- Tricuspid | 46 (12.1) | 7 (11.8) | 0.99 |
- Pulmonary | 4 (1.05) | 1(1.6) | 0.51 |
- IE on interventricular communication, n (%) | 4 (1.05) | 0 | 1 |
Acquisition setting, n (%) | |||
Community | 221(58.5) | 17(28.8) | |
Nosocomial | 128(33.9) | 37(62.7) | 0.0001 |
Healthcare-related | 29(7.7) | 5(8.5) | |
Decade of endocarditis onset, n (%) | |||
1985–1999 | 61 (16.1) | 7(11.8) | 0.4 |
2000–2009 | 136 (35.9) | 20 (33.9) | 0.756 |
2010–2017 | 180 (47.6) | 32 (54.2) | 0.344 |
History of: n (%) | |||
- previous IE | 18 (4.8) | 7(11.9) | 0.64 |
- valve disease on native valve | 171 (45.2) | 24(40.7) | 0.42 |
- Rheumatic | 51 (13.5) | 7(11.9) | 0.68 |
- Myxoid degeneration and/or mitral prolapse | 26 (6.9) | 3 (5.1) | 0.78 |
- Degenerative/calcified | 58 (15.3) | 10 (16.9) | 0.8 |
- Congenital valve disease | 27 (7.1) | 0 | 0.037 |
- Heart disease | 98 (25.9) | 21(35.6) | 0.81 |
- Cardiomyopathy | 35(9.3) | 12(20.4) | 0.01 |
- COPD | 46(12.2) | 18(30.5) | 0.0001 |
- Diabetes Mellitus | 91 (24.1) | 18 (30.5) | 0.22 |
- Peptic ulcer | 5 (1.3) | 3(5.1) | 0.12 |
- Arterial hypertension | 123 (32.5) | 26(44.1) | 0.09 |
- Peripheral vascular disease | 21(5.6) | 6(10.2) | 0.24 |
- Stroke | 21(5.6) | 5(8.5) | 0.37 |
- Dementia | 6(1.6) | 2(3.4) | 0.3 |
- Active neoplasm | 30 (7.9) | 6(10.2) | 0.61 |
- Colonic polyposis | 8 (2.1) | 4 (6.8) | 0.13 |
- Transplant (*) | 5 (1.3) | 0 | 1 |
- Chronic liver disease, n (%) | 49 (12.9) | 6 (10.2) | 0.54 |
- Child-Pugh A | 29 (59.2) | 1(16.7) | |
- Child-Pugh B | 3(6.1) | 1(16.7) | 0.7 |
- Child-Pugh C | 3(6.1) | 1(16.7) | |
- Hemodialysis | 29 (7.7) | 0 | 0.02 |
- Kidney failure | 80 (21.2) | 11(18.6) | 0.6 |
-IVDA | 38(10.1) | 2(3.4) | 0.097 |
Charlson index, median (IQR) | 2(0–3) | 3(1–4) | 0.006 |
Previous invasive procedure or infection focus, n (%) | 216 (57.1) | 47(79.7) | 0.001 |
Vascular | 148 (68.5) | 27(57.4) | 0.63 |
Urinary (catheter) | 7(3.2) | 4(8.5) | 0.08 |
Abdominal | 3(1.4) | 2(4.3) | 0.19 |
Dental | 5(2.3) | 0 | 1 |
Locomotor | 6(2.8) | 3(6.4) | 0.17 |