Table 3 Socio-demographic and clinical factors associated with severe adverse events
Characteristic at baseline | Case/n | Crude model | Adjusted model | ||
|---|---|---|---|---|---|
OR(95%CI) | P | OR(95%CI) | P | ||
Age, years | |||||
  < 50 | 77/428 | 1 |  |  |  |
  ≥ 50 | 8/46 | 0.96(0.43–2.14) | 0.920 |  |  |
Marital status | |||||
 Single/divorced/widowed | 63/367 | 0.80(0.47–1.38) | 0.421 |  |  |
 Married/common law marriage | 22/107 | 1 |  |  |  |
Years of Education | |||||
  ≤ 9 | 18/88 | 1.22(0.69–2.19) | 0.495 |  |  |
  > 9 | 67/386 | 1 |  |  |  |
BMI, kg/m2 | |||||
  < 24 | 54/351 | 1 |  | 1 |  |
  ≥ 24 | 31/123 | 1.85(1.12–3.06) | 0.016 | 1.77(1.03–3.02) | 0.038 |
CD4+, cells/mm3 | |||||
  ≤ 199 | 21/120 | 1 |  |  |  |
 200–349 | 22/145 | 0.84(0.44–1.62) | 0.843 |  |  |
 350–499 | 24/124 | 1.13(0.59–2.16) | 0.656 |  |  |
  ≥ 500 | 18/85 | 1.27(0.63–2.56) | 0.509 |  |  |
Viral load, cells/ml | |||||
  < 100,000 | 64/382 | 1 |  | 1 |  |
  ≥ 100,000 | 21/92 | 1.47(0.84–2.56) | 0.175 | 1.55(0.86–2.81) | 0.148 |
Syphilis Status | |||||
 Yes | 24/149 | 0.83(0.50–1.40) | 0.483 |  |  |
 No | 61/325 | 1 |  |  |  |
Hepatitis Status | |||||
 Positive | 7/31 | 1.37(0.57–3.28) | 0.487 |  |  |
 Negative | 78/443 | 1 |  |  |  |
WHO Clinical Stage | |||||
 I + II | 75/433 | 1 |  |  |  |
 III + IV | 10/41 | 1.54(0.72–3.28) | 0.262 |  |  |
Pre-existing AE | |||||
 Yes | 78/403 | 2.19(0.97–4.97) | 0.060 | 0.96(0.39–2.34) | 0.924 |
 No | 7/71 | 1 |  | 1 |  |
Pre-existing multiple AE | |||||
 Yes | 49/167 | 3.13(1.93–5.06) | < 0.001 | 2.72(1.59–4.64) | < 0.001 |
 No | 36/307 | 1 |  | 1 |  |
Pre-existing severe AE | |||||
 Yes | 18/36 | 5.54(2.74–11.19) | < 0.001 | 5.58(2.65–11.73) | < 0.001 |
 No | 67/438 | 1 |  | 1 |  |