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Table 2 Unconditional logistic multiple regression model of risk and protection factors for tuberculosis

From: Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

Features Level All the groups G1 + G3 vs. G2 + G4 HIV-1 positive individuals G1 vs. G2
With TB
(G1 + G3)
N = 112
Without TB
(G2 + G4)
N = 50
aORa 95%CI P-valueb With TB (G1)
N = 88
Without TB (G2)
N = 24
aOR 95%CI P-value
Gender Male 86 (76.79) 27 (54) Ref 70 (79.55) 16 (66.67) Ref
Female 26 (23.21) 23 (46) 0.33 0.13–0.8 0.014 18 (20.45) 8 (33.33) 0.49 0.17–1.43 0.192
HLA-B*08 not carriers 105 (93.75) 41 (82) Ref 82 (93.18) 21 (87.5) Ref
carriers 7 (6.25) 9 (18) 0.23 0.06–089 0.033 6 (6.82) 3 (12.5) 0.53 0.1–2.77 0.450
KIR2DL3 carriers 105 (93.75) 44 (88) Ref 84 (95.45) 19 (79.17) Ref
not carriers 7 (6.25) 6 (12) 0.52 0.14–1.89 0.319 4 (4.55) 5 (20.83) 0.18 0.04–0.74 0.034
KIR2DS2 not carriers 50 (44.64) 29 (58) Ref 42 (47.73) 14 (58.33) Ref
carriers 62 (55.36) 21 (42) 2.39 1.03–5.54 0.043 46 (52.27) 10 (41.67) 1.74 0.66–4.64 0.265
HLA-C*07c carriers 37 (33.64)c 20 (40) 0.75 0.32–1.71 0.489 28 (32.56)c 12 (50) 0.32 0.11–0.94 0.038
not carriers 73 (66.36)c 30 (60) Ref 58 (67.44)c 12 (50) Ref
  1. aOdds ratios were adjusted by gender, skin color, education, HIV status, CD4 count, and CD4/CD8 ratio when appropriate. bP-values were calculated using the unconditional logistic regression model. Differences were considered significant with a value of * P < 0.05. Significant P-values are labeled in bold. cThe HLA-C determination was not possible for two individuals from G1. So, when considering this variable, N (G1) = 86 and N (G1 + G3) = 110
  2. N number of individuals in each group, aOR adjusted odds ratio, 95% CI 95% confidence interval, REF Reference, G1 group 1, G2 group 2, G3 group 3. G4 group 4