Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

Table 2 Unconditional logistic multiple regression model of risk and protection factors for tuberculosis

Features	Level	All the groups		G1 + G3 vs. G2 + G4			HIV-1 positive individuals		G1 vs. G2
Features	Level	With TB (G1 + G3) N = 112	Without TB (G2 + G4) N = 50	aOR^a	95%CI	P-value^b	With TB (G1) N = 88	Without TB (G2) N = 24	aOR	95%CI	P-value
Gender	Male	86 (76.79)	27 (54)	Ref			70 (79.55)	16 (66.67)	Ref
Gender	Female	26 (23.21)	23 (46)	0.33	0.13–0.8	0.014	18 (20.45)	8 (33.33)	0.49	0.17–1.43	0.192
HLA-B*08	not carriers	105 (93.75)	41 (82)	Ref			82 (93.18)	21 (87.5)	Ref
HLA-B*08	carriers	7 (6.25)	9 (18)	0.23	0.06–089	0.033	6 (6.82)	3 (12.5)	0.53	0.1–2.77	0.450
KIR2DL3	carriers	105 (93.75)	44 (88)	Ref			84 (95.45)	19 (79.17)	Ref
KIR2DL3	not carriers	7 (6.25)	6 (12)	0.52	0.14–1.89	0.319	4 (4.55)	5 (20.83)	0.18	0.04–0.74	0.034
KIR2DS2	not carriers	50 (44.64)	29 (58)	Ref			42 (47.73)	14 (58.33)	Ref
KIR2DS2	carriers	62 (55.36)	21 (42)	2.39	1.03–5.54	0.043	46 (52.27)	10 (41.67)	1.74	0.66–4.64	0.265
HLA-C*07^c	carriers	37 (33.64)^c	20 (40)	0.75	0.32–1.71	0.489	28 (32.56)^c	12 (50)	0.32	0.11–0.94	0.038
HLA-C*07^c	not carriers	73 (66.36)^c	30 (60)	Ref			58 (67.44)^c	12 (50)	Ref

^aOdds ratios were adjusted by gender, skin color, education, HIV status, CD4 count, and CD4/CD8 ratio when appropriate. ^bP-values were calculated using the unconditional logistic regression model. Differences were considered significant with a value of ^* P < 0.05. Significant P-values are labeled in bold. ^cThe HLA-C determination was not possible for two individuals from G1. So, when considering this variable, N (G1) = 86 and N (G1 + G3) = 110
N number of individuals in each group, aOR adjusted odds ratio, 95% CI 95% confidence interval, REF Reference, G1 group 1, G2 group 2, G3 group 3. G4 group 4

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