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Table 2 Dosage advice options for intervention

From: The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial

Dosage adjustment Dose recommendations
Dose increase Increase dose administration frequency by 25–50%
Increase dose by 25–50% with same dosing frequency
Dose reduction Decrease dose administration frequency
Decrease dose by 25–50% with same dosing frequency
Withhold administration for 1 day