Table 4 Performance of WHO, CDC and ECDC case definitions tested for detection of influenza globally and by age groups, Dielmo and Ndiop study, Senegal, 2013–2016
Case definitions | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV* % (95% CI) | NPV† % (95% CI) |
|---|---|---|---|---|
All cases | ||||
WHO | 81.0 (77.0–85.0) | 52.0 (49.1–54.5) | 32.0 (30.0–35.0) | 91.0 (89.0–93.1) |
CDC | 81.0 (77.0–85.1) | 52.0 (49.1–54.5) | 32.0 (30.0–35.0) | 91.0 (88.5–93.1) |
ECDC | 82.0 (77.5–85.5) | 50.5 (48.0–53.2) | 31.2 (28.2–34.2) | 91.0 (89.0–93.1) |
Age groups (years) | ||||
0 - < 2 | ||||
WHO | 82.0 (70.4–93.2) | 36.0 (30.0–41.5) | 18.0 (13.0 -- 23.3) | 92.0 (87.0–97.3) |
CDC | 82.0 (70.4–93.2) | 36.4 (30.6–42.3) | 18.0 (12.5–23.3) | 92.2 (86.0–97.4) |
ECDC | 84.1 (73.3–95.0) | 36.0 (30.0–41.5) | 18.2 (13.0–23.5) | 93.0 (88.0–98.0) |
2 - < 5 | ||||
WHO | 86.0 (78.3–94.0) | 38.0 (32.3–44.0) | 28.0 (22.3–33.6) | 90.5 (85.2–96.0) |
CDC | 86.0 (77.0–94.0) | 38.2 (32.5–44.0) | 28.2 (22.5–34.0) | 90.6 (85.3–96.0) |
ECDC | 86.0 (78.2–94.0) | 38.0 (31.2–43.6) | 28.0 (22.3–34.0) | 90.5 (85.1–96.0) |
5 - < 15 | ||||
WHO | 84.0 (77.3–90.1) | 58.0 (53.2–62.5) | 37.2 (31.6–42.7) | 92.2 (89.0–95.4) |
CDC | 84.4 (78.2–91.0) | 57.0 (52.3–61.6) | 37.0 (31.5–42.5) | 92.5 (89.3–95.6) |
ECDC | 84.5 (78.2–91.0) | 56.0 (51.3–61.0) | 36.5 (31.0–42.0) | 92.3 (89.1–95.5) |
15 - < 50 | ||||
WHO | 72.0 (62.2–81.3) | 69.0 (63.3–74.1) | 41.0 (33.1–49.0) | 89.0 (85.0–93.2) |
CDC | 72.0 (62.2–81.3) | 69.0 (63.6–74.4) | 41.2 (33.3–49.2) | 89.0 (85.0–93.1) |
ECDC | 72.0 (62.2–81.3) | 66.0 (60.3–71.4) | 39.0 (31.4–46.6) | 88.5 (84.2–93.0) |
≥ 50 | ||||
WHO | 81.0 (64.2–980) | 65.3 (52.0–78.6) | 50.0 (33.2–67.0) | 88.5 (78.0–99.1) |
CDC | 81.0 (64.1–98.0) | 65.0 (51.0–78.1) | 50.0 (33.1–67.0) | 88.6 (78.1–99.2) |
ECDC | 81.0 (64.1–98.0) | 65.0 (51.1–78.1) | 50.0 (33.2–67.0) | 88.6 (78.1–99.1) |