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Table 4 Performance of WHO, CDC and ECDC case definitions tested for detection of influenza globally and by age groups, Dielmo and Ndiop study, Senegal, 2013–2016

From: Performance of case definitions and clinical predictors for influenza surveillance among patients followed in a rural cohort in Senegal

Case definitions Sensitivity % (95% CI) Specificity % (95% CI) PPV* % (95% CI) NPV % (95% CI)
All cases
 WHO 81.0 (77.0–85.0) 52.0 (49.1–54.5) 32.0 (30.0–35.0) 91.0 (89.0–93.1)
 CDC 81.0 (77.0–85.1) 52.0 (49.1–54.5) 32.0 (30.0–35.0) 91.0 (88.5–93.1)
 ECDC 82.0 (77.5–85.5) 50.5 (48.0–53.2) 31.2 (28.2–34.2) 91.0 (89.0–93.1)
Age groups (years)
0 - <  2
  WHO 82.0 (70.4–93.2) 36.0 (30.0–41.5) 18.0 (13.0 -- 23.3) 92.0 (87.0–97.3)
  CDC 82.0 (70.4–93.2) 36.4 (30.6–42.3) 18.0 (12.5–23.3) 92.2 (86.0–97.4)
  ECDC 84.1 (73.3–95.0) 36.0 (30.0–41.5) 18.2 (13.0–23.5) 93.0 (88.0–98.0)
2 - <  5
  WHO 86.0 (78.3–94.0) 38.0 (32.3–44.0) 28.0 (22.3–33.6) 90.5 (85.2–96.0)
  CDC 86.0 (77.0–94.0) 38.2 (32.5–44.0) 28.2 (22.5–34.0) 90.6 (85.3–96.0)
  ECDC 86.0 (78.2–94.0) 38.0 (31.2–43.6) 28.0 (22.3–34.0) 90.5 (85.1–96.0)
5 - <  15
  WHO 84.0 (77.3–90.1) 58.0 (53.2–62.5) 37.2 (31.6–42.7) 92.2 (89.0–95.4)
  CDC 84.4 (78.2–91.0) 57.0 (52.3–61.6) 37.0 (31.5–42.5) 92.5 (89.3–95.6)
  ECDC 84.5 (78.2–91.0) 56.0 (51.3–61.0) 36.5 (31.0–42.0) 92.3 (89.1–95.5)
15 - <  50
  WHO 72.0 (62.2–81.3) 69.0 (63.3–74.1) 41.0 (33.1–49.0) 89.0 (85.0–93.2)
  CDC 72.0 (62.2–81.3) 69.0 (63.6–74.4) 41.2 (33.3–49.2) 89.0 (85.0–93.1)
  ECDC 72.0 (62.2–81.3) 66.0 (60.3–71.4) 39.0 (31.4–46.6) 88.5 (84.2–93.0)
≥ 50
  WHO 81.0 (64.2–980) 65.3 (52.0–78.6) 50.0 (33.2–67.0) 88.5 (78.0–99.1)
  CDC 81.0 (64.1–98.0) 65.0 (51.0–78.1) 50.0 (33.1–67.0) 88.6 (78.1–99.2)
  ECDC 81.0 (64.1–98.0) 65.0 (51.1–78.1) 50.0 (33.2–67.0) 88.6 (78.1–99.1)
  1. PPV*= Positive Predictive Value; NPV= Negative Predictive Value