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Table 9 Decreasing levels of immunocompromised probability (Column 6) to simulate vaccination combined with select parameter combinations from TableĀ 7 (Scenarios 6.1, 6.2, 18.1, 18.2, 22.1, 22.2, 25.1, and 25.2). The eight selected scenarios varied levels of antimicrobial stewardship, ward-room terminal cleaning, and HCW basic compliance with non-quarantined patients while HCW compliance with quarantined patients remained at baseline (60%). (Note that the second decimal place in the scenario number indicates the varying levels of immunocompromised probabilities while XX.X represents the original scenario number from TableĀ 7)

From: Comparing intervention strategies for reducing Clostridioides difficile transmission in acute healthcare settings: an agent-based modeling study

Scenario number Half-daily antibiotic prob Targeted antib reduction scenario Prob of sufficient cleaning HCW basic compliance Immuno-compromised prob Change from median baseline colonizations Change from baseline median infections
6.1.0 0.27* 2 0.8 0.75 0.10* -19.25% -17.19%
6.1.1 0.27* 2 0.8 0.75 0.05 -20.19 -56.43%
6.1.2 0.27* 2 0.8 0.75 0.01 -20.88% -89.17%
6.2.0 0.27* 2 0.8 1 0.10* -23.79% -19.81%
6.2.1 0.27* 2 0.8 1 0.05 -23.55% -60.44%
6.2.2 0.27* 2 0.8 1 0.01 -23.96% -91.83%
18.1.0 0.243 3 0.8 0.75 0.10* -35.16% -27.12%
18.1.1 0.243 3 0.8 0.75 0.05 -35.55% -62.96%
18.1.2 0.243 3 0.8 0.75 0.01 -36.27% -92.90%
18.2.0 0.243 3 0.8 1 0.10* -38.88% -26.37%
18.2.1 0.243 3 0.8 1 0.05 -38.85% -64.25%
18.2.2 0.243 3 0.8 1 0.01 -39.38% -92.83%
22.1.0 0.216 2 0.2 0.75 0.10* -29.71% -20.95%
22.1.1 0.216 2 0.2 0.75 0.05 -30.28% -60.47%
22.1.2 0.216 2 0.2 0.75 0.01 -31.49% -92.20%
22.2.0 0.216 2 0.2 1 0.10* -34.83% -23.00%
22.2.1 0.216 2 0.2 1 0.05 -35.05% -61.37%
22.2.2 0.216 2 0.2 1 0.01 -35.52% -92.23%
25.1.0 0.216 3 0.2 0.75 0.10* -37.21% -26.47%
25.1.1 0.216 3 0.2 0.75 0.05 -38.73% -64.58%
25.1.2 0.216 3 0.2 0.75 0.01 41.87% -92.38%
25.2.0 0.216 3 0.2 1 0.10* -41.87% -29.20%
25.2.1 0.216 3 0.2 1 0.05 -42.34% -63.98%
25.2.2 0.216 3 0.2 1 0.01 -42.91% -93.08%
  1. *Baseline value