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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: Genotype-Informed Versus Empiric Management Of VirEmia (GIVE MOVE): study protocol of an open-label randomised clinical trial in children and adolescents living with HIV in Lesotho and Tanzania

Fig. 2

SPIRIT diagram of study procedures. Footnotes: 1 Conducted 24 weeks (range: 20–28 weeks) after the visit in which the follow-up viral load result (control arm) or the GRT result (intervention arm) is first available; may coincide with another study visit. 2 May be delayed upon evidence of poor adherence, defined as a pill count of <90% and/or a self-reported period of no drug intake of ≥2 days in the last 4 weeks. 3 In intervention arm: informed by GRT result. 4 Clinical information at ART initiation; previous ART regimens; exposure to prevention to mother-to-child transmission strategies. 5 Height, weight, middle upper arm circumference (if aged <5 years), nutritional status. 6 WHO stage; co-morbidities; symptoms and side-effects; new hospitalisation. 7 Female participants aged ≥12 years. GRT: genotypic resistance testing; VL: viral load

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