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Table 1 Characteristics of analyzed individuals with laboratory-positive non-severe and severe COVID-19, Mexico 2020

From: Male gender and kidney illness are associated with an increased risk of severe laboratory-confirmed coronavirus disease

 

Overall

Non-severe

Severe

p

n = 740

n = 533

n = 207

Sex

 Female

316 (42.7)

257 (48.2)

59 (28.5)

<  0.001

 Male

424 (57.3)

276 (51.8)

148 (71.5)

 

Age (years) a

43.7 ± 14.9

40.0 ± 13.0

53.1 ± 15.4

<  0.001

Age group (years)

 15–29

141 (19.1)

126 (23.6)

15 (7.2)

<  0.001

 30–44

281 (38.0)

240 (45.1)

41 (19.8)

 

 45–59

210 (28.3)

122 (22.9)

88 (42.6)

 

  ≥ 60

108 (14.6)

45 (8.4)

63 (30.4)

 

Received NAIs (any)

 No

734 (99.2)

529 (99.2)

205 (99.0)

0.769

 Yes

6 (0.8)

4 (0.8)

2 (1.0)

 

Received antyperitc drugs (any)

 No

326 (44.1)

227 (42.6)

99 (47.8)

0.198

 Yes

414 (55.9)

306 (57.4)

108 (52.2)

 

Antipyretic drug received b

Acetaminophen

372 (89.9)

291 (95.1)

81 (75.0)

<  0.001

 Metamizole

11 (2.7)

5 (1.6)

6 (5.6)

 

 Ibuprofen

10 (2.3)

4 (1.3)

6 (5.6)

 

 Other

21 (5.1)

6 (2.0)

15 (13.8)

 

Received influenza vaccine c

 No

622 (84.1)

440 (82.6)

182 (87.9)

0.073

 Yes

118 (15.9)

93 (17.4)

25 (12.1)

 

Elapsed days from symptoms onset to health-care seeking

  < 1

347 (46.9)

253 (47.5)

94 (45.4)

<  0.001

 1–3

182 (24.6)

148 (27.7)

34 (16.4)

 

 4 or above

211 (28.5=

132 (24.8)

79 (38.2)

 

Hospital admission

 No

470 (63.5)

470 (88.2)

0 (0)

<  0.001

 Yes

270 (36.5)

63 (11.8)

207 (100)

 

Acute symptoms profile

Cough (yes)

657 (88.8)

466 (87.4)

191 (92.3)

0.061

Fever (yes)

641 (86.6)

451 (84.6)

190 (91.8)

0.010

Headache (yes)

632 (85.4)

464 (87.1)

168 (81.2)

0.041

Myalgia/Arthralgia (yes)

572 (77.3)

423 (79.4)

149 (72.0)

0.031

Odynophagia (yes)

407 (55.0)

310 (58.2)

97 (46.9)

0.006

Chills (yes)

403 (54.5)

287 (53.8)

116 (56.0)

0.591

Rhinorrhea (yes)

353 (47.7)

276 (51.8)

77 (37.2)

<  0.001

Thoracic pain (yes)

282 (38.1)

171 (32.1)

111 (53.6)

<  0.001

Diarrhea (yes)

137 (18.5)

104 (19.5)

33 (15.9)

0.262

Polypnea (yes)

27 (3.6)

5 (0.9)

22 (10.6)

<  0.001

Personal history of

Tobacco use (current, yes)

80 (10.8)

47 (8.9)

32 (15.6)

0.009

Obesity (BMI 30 or higher) (yes)

162 (21.9)

100 (18.8)

61 (29.7)

0.001

Arterial hypertension (yes)

148 (20.0)

74 (13.9)

74 (35.6)

<  0.001

Cardiovascular disease (yes)

20 (2.7)

8 (1.5)

12 (5.9)

0.001

Type 2 diabetes mellitus (yes)

108 (14.6)

51 (9.5)

58 (27.8)

<  0.001

Asthma (yes)

33 (4.4)

22 (4.2)

10 (4.9)

0.676

COPD (yes)

27 (3.7)

9 (1.7)

18 (8.8)

<  0.001

Chronic kidney disease (yes)

13 (1.8)

3 (0.6)

10 (4.9)

<  0.001

Immunosuppression (yes)

19 (2.5)

8 (1.5)

10 (4.9)

<  0.001

HIV infection (yes)

5 (0.7)

3 (0.6)

2 (1.0)

0.549

  1. Abbreviations: COVID-19 Coronavirus disease 2019, NAIs Neuraminidase inhibitors, COPD Chronic obstructive pulmonary disease, HIV Human immunodeficiency virus
  2. Notes: 1) SuperScript™ III Platinum™ One-Step qRT-PCR Kits were used to confirm the COVID-19; 2) The absolute and relative (%) frequencies are presented, unless otherwise specified. 2) p-value from chi-square o t-tests as corresponding
  3. a The arithmetic mean ± standard deviation is presented
  4. b Among 414 subjects (non-severe disease, n = 306; severe disease, n = 108) in whom the use of antipyretic drugs was documented before healthcare seeking
  5. c During the same influenza season than acute COVID-19 onset