Fig. 3

Microscopy of the autopsy showed epithelioid cell granulomas on the liver (a, b), spleen (c, d) and heart (e), and Langhans giant cells on the urinary bladder (f). Microscopy of the lung specimen revealed pulmonary oedema with hyaline membranes (g) and patchy paraseptal fibrosis with remodelling of the lung architecture (h), suggesting acute exacerbation of interstitial pneumonitis. Bar in A = 20 μm. Bar in B, D, G = 200 μm. Bar in C, E, F = 50 μm. Bar in H = 1 mm. [A: haematoxylin–eosin (HE), × 400; B, D: CD68(Kp-1;DAKO)-IHC, × 100; C, E, F: HE, × 200; G: HE, × 40; H: EvG, × 12.5]