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Table 4 Sensitivity comparisons of plasma IS6110 & IS1081-dPCR assay with routine diagnostic tests in diagnosis of TB

From: Evaluation of digital PCR assay in detection of M.tuberculosis IS6110 and IS1081 in tuberculosis patients plasma

Methods

Number of TB Patients

Sensitivity

p value

IS6110 & IS1081-dPCR vs Smear microscope

108

38.0% (41/108) vs 93.5% (101/108)

0.000

IS6110 & IS1081-dPCR vs Mycobacterial culture

66

34.8% (23/66) vs 97.0% (64/66)

0.000

IS6110 & IS1081-dPCR vs IS6110 qPCR

40

57.5% (23/40) vs 22.5% (9/40)

0.031

  1. qPCR quantitative polymerase chain reaction; McNemar test was used to calculate p value