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Table 3 Diagnostic performance of plasma IS6110- and IS1081- dPCR assay for Disseminated TB

From: Evaluation of digital PCR assay in detection of M.tuberculosis IS6110 and IS1081 in tuberculosis patients plasma

  Cut-off point (copies/20 μl) AUC Sensitivity(%) Specificity(%) LR+ LR- PPV(%) NPV(%)
Disseminated TB (16) compared with HC (n = 106)
 IS6110-dPCR 16 0.98 (0.97–1.00) 77.8 (47.6–92.7) 99.1 (94.9–100.0) 86.1 (12.1–614.4) 0.2 (0.1–0.5) 92.9 (64.7–99.9) 97.2 (92.1–99.4)
 IS1081-dPCR 14 0.95 (0.91–0.99) 37.5 (16.2–64.6) 99.1 (94.9–100.0) 39.8 (5.1–309.0) 0.6 (0.4–0.9) 85.7 (38.1–99.8) 91.3 (84.6–95.8)
  1. AUC area under receiver operating characteristic (ROC) curve, LR+ positive likelihood ratio, LR- negative likelihood ratio, PPV positive predictive value, NPV negative predictive value