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Table 2 Function analysis of the 35 genes in module 1

From: Gene network in pulmonary tuberculosis based on bioinformatic analysis

Term Description Count FDR
Biological Process (GO)
 GO:0006952 Defense response 28 of 1234 2.39E-24
 GO:0002376 Immune system process 31 of 2370 1.2E-21
 GO:0051707 Response to other organism 22 of 835 4.56E-19
 GO:0006955 Immune response 25 of 1560 9.48E-18
 GO:0002682 Regulation of immune system process 24 of 1391 1.52E-17
Molecular Function (GO)
 GO:0019956 Chemokine binding 4 of 22 0.0000233
 GO:0004950 Chemokine receptor activity 4 of 27 0.0000243
 GO:0019957 C-C chemokine binding 3 of 11 0.000088
 GO:0016493 C-C chemokine receptor activity 3 of 13 0.00011
 GO:0003725 Double-stranded RNA binding 4 of 70 0.00028
Cellular Component (GO)
 GO:0009897 External side of plasma membrane 9 of 223 2.93E-08
 GO:0009986 Cell surface 11 of 690 0.0000015
 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex 2 of 2 0.00064
 GO:0005887 Integral component of plasma membrane 11 of 1564 0.0017
 GO:0044459 Plasma membrane part 13 of 2651 0.0083
KEGG Pathways
 hsa04060 Cytokine-cytokine receptor interaction 8 of 263 0.00000133
 hsa04620 Toll-like receptor signaling pathway 5 of 102 0.0000409
 hsa05162 Measles 5 of 133 0.0000955
 hsa05168 Herpes simplex infection 5 of 181 0.00031
 hsa05134 Legionellosis 3 of 54 0.0019
Reactome Pathways
 HSA-168256 Immune system 22 of 1925 3.84E-12
 HSA-1280215 Cytokine signaling in immune system 12 of 654 5.29E-08
 HSA-913531 Interferon signaling 7 of 189 0.00000192
 HSA-168249 Innate immune system 12 of 1012 0.0000032
 HSA-909733 Interferon alpha/beta signaling 5 of 66 0.0000039
PFAM Protein Domains
 PF01582 TIR domain 4 of 22 0.0000057
 PF13855 Leucine rich repeat 4 of 187 0.0051
 PF13676 TIR domain 2 of 11 0.0051
 PF13306 Leucine rich repeats (6 copies) 3 of 88 0.0051
 PF01463 Leucine rich repeat C-terminal domain 2 of 12 0.0051
INTERPRO Protein Domains and Features   
 IPR035897 TIR domain superfamily 4 of 26 0.00000766
 IPR000355 Chemokine receptor family 4 of 21 0.00000766
 IPR000157 TIR domain 4 of 22 0.00000766
 IPR024644 Interferon-induced protein 44 family 2 of 2 0.00031
 IPR000483 Cysteine-rich flanking region, C-terminal 4 of 83 0.00031