Table 2 Function analysis of the 35 genes in module 1
From: Gene network in pulmonary tuberculosis based on bioinformatic analysis
Term | Description | Count | FDR |
|---|---|---|---|
Biological Process (GO) | |||
 GO:0006952 | Defense response | 28 of 1234 | 2.39E-24 |
 GO:0002376 | Immune system process | 31 of 2370 | 1.2E-21 |
 GO:0051707 | Response to other organism | 22 of 835 | 4.56E-19 |
 GO:0006955 | Immune response | 25 of 1560 | 9.48E-18 |
 GO:0002682 | Regulation of immune system process | 24 of 1391 | 1.52E-17 |
Molecular Function (GO) | |||
 GO:0019956 | Chemokine binding | 4 of 22 | 0.0000233 |
 GO:0004950 | Chemokine receptor activity | 4 of 27 | 0.0000243 |
 GO:0019957 | C-C chemokine binding | 3 of 11 | 0.000088 |
 GO:0016493 | C-C chemokine receptor activity | 3 of 13 | 0.00011 |
 GO:0003725 | Double-stranded RNA binding | 4 of 70 | 0.00028 |
Cellular Component (GO) | |||
 GO:0009897 | External side of plasma membrane | 9 of 223 | 2.93E-08 |
 GO:0009986 | Cell surface | 11 of 690 | 0.0000015 |
 GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex | 2 of 2 | 0.00064 |
 GO:0005887 | Integral component of plasma membrane | 11 of 1564 | 0.0017 |
 GO:0044459 | Plasma membrane part | 13 of 2651 | 0.0083 |
KEGG Pathways | |||
 hsa04060 | Cytokine-cytokine receptor interaction | 8 of 263 | 0.00000133 |
 hsa04620 | Toll-like receptor signaling pathway | 5 of 102 | 0.0000409 |
 hsa05162 | Measles | 5 of 133 | 0.0000955 |
 hsa05168 | Herpes simplex infection | 5 of 181 | 0.00031 |
 hsa05134 | Legionellosis | 3 of 54 | 0.0019 |
Reactome Pathways | |||
 HSA-168256 | Immune system | 22 of 1925 | 3.84E-12 |
 HSA-1280215 | Cytokine signaling in immune system | 12 of 654 | 5.29E-08 |
 HSA-913531 | Interferon signaling | 7 of 189 | 0.00000192 |
 HSA-168249 | Innate immune system | 12 of 1012 | 0.0000032 |
 HSA-909733 | Interferon alpha/beta signaling | 5 of 66 | 0.0000039 |
PFAM Protein Domains | |||
 PF01582 | TIR domain | 4 of 22 | 0.0000057 |
 PF13855 | Leucine rich repeat | 4 of 187 | 0.0051 |
 PF13676 | TIR domain | 2 of 11 | 0.0051 |
 PF13306 | Leucine rich repeats (6 copies) | 3 of 88 | 0.0051 |
 PF01463 | Leucine rich repeat C-terminal domain | 2 of 12 | 0.0051 |
INTERPRO Protein Domains and Features | Â | Â | |
 IPR035897 | TIR domain superfamily | 4 of 26 | 0.00000766 |
 IPR000355 | Chemokine receptor family | 4 of 21 | 0.00000766 |
 IPR000157 | TIR domain | 4 of 22 | 0.00000766 |
 IPR024644 | Interferon-induced protein 44 family | 2 of 2 | 0.00031 |
 IPR000483 | Cysteine-rich flanking region, C-terminal | 4 of 83 | 0.00031 |