Table 5 Comparison of patients with catheter removal receiving long- and short-duration antibiotic in the phase 2 study
Characteristics and outcomes | Long-duration group (N = 33) | Short-duration group (N = 11) | p-value |
|---|---|---|---|
Characteristics | |||
Age (year) | 67 (18–81) | 68 (24–81) | 0.979 |
Gender | |||
Male | 16 (48.5%) | 5 (45.5%) | 1.000 |
Female | 17 (51.5%) | 6 (54.5%) | 1.000 |
Charlson comorbidity index (score) | 5 (0–12) | 4 (0–10) | 0.936 |
Underlying diseases | |||
HIV infection | 0 (0.0%) | 0 (0.0%) | – |
Cancer | 7 (21.2%) | 3 (27.3%) | 0.692 |
Liver disease | 1 (3.0%) | 1 (9.1%) | 0.442 |
Renal disease | 16 (48.5%) | 4 (36.4%) | 0.728 |
COPD | 1 (3.0%) | 0 (0.0%) | 1.000 |
Diabetes mellitus | 13 (39.4%) | 5 (45.5%) | 0.738 |
Hematological disease | 2 (6.1%) | 1 (9.1%) | 1.000 |
Cardiovascular disease | 8 (24.2%) | 7 (63.6%) | 0.028a |
Trauma | 1 (3.0%) | 0 (0.0%) | 1.000 |
Immunocompromised status | 6 (18.2%) | 2 (18.2%) | 1.000 |
Microbial etiology | |||
Monomicrobial | 31 (93.9%) | 10 (90.9%) | 1.000 |
Polymicrobial | 2 (6.1%) | 1 (9.1%) | 1.000 |
Origin of infection | |||
Healthcare-associated | 9 (27.3%) | 1 (9.1%) | 0.408 |
Nosocomial | 24 (72.7%) | 10 (90.9%) | 0.408 |
ICU admission at onset of infection | 13 (39.4%) | 4 (36.4%) | 1.000 |
Surgery at present admission | 18 (54.5%) | 6 (54.5%) | 1.000 |
Type of catheter | |||
Tunneled hemodialysis catheter | 10 (30.3%) | 2 (18.2%) | 0.698 |
Short-term central venous catheter or arterial catheter | 19 (57.6%) | 4 (36.4%) | 0.303 |
Long-term central venous catheter or port | 4 (12.1%) | 5 (45.5%) | 0.030a |
Total duration of therapy (day) | 17 (14–30) | 7 (7–10) | < 0.001a |
Duration of therapy after catheter removal (day) | 14 (1–23) | 7 (7–7) | < 0.001a |
Outcome | |||
Relapse | 1 (3.0%) | 0 (0.0%) | 1.000 |
Death | 4 (12.1%) | 1 (9.1%) | 1.000 |
Time to next antibiotic use (hour) | 357.25 (54.0–444.0) | 224.0 (176.0–312.75) | 0.400 |
Indication of next antibiotic used | |||
New infectious episode | 3 (9.1%) | 2 (18.2%) | 1.000 |
Non-infectious episode | 0 (0.0%) | 0 (0.0%) | – |
Relapse | 1 (3.0%) | 0 (0.0%) | 1.000 |
Undetermined episode | 0 (0.0%) | 1 (9.1%) | 0.429 |