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Table 1 Comparison of characteristics of patients with and without at least one potential drug-drug interaction

From: Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda

  One or more pDDI in study period
n = 959
No pDDI in study period
n = 115
p value*
Demographics
Age    0.477
17–30 316 (32.9) 42 (36.5)  
31–40 403 (42.0) 48 (41.7)  
41–50 203 (21.2) 20 (17.4)  
51+ 37 (3.9) 5 (4.3)  
Gender    0.070
Male 560 (58.4) 57 (49.6)  
Female 399 (41.6) 58 (50.4)  
Baseline diagnostics and investigations
CD4 (cells/mm3) 18 (7–55) 35 (16–209) 0.040
Diagnosis of cryptococcal meningitis    <.001
No 364 (38.0) 105 (91.3)  
Yes 595 (62.0) 10 (8.7)  
Diagnosis of tuberculosis    0.049
No 852 (88.8) 109 (94.8)  
Yes 107 (11.2) 6 (5.2)  
Diagnosis of malaria    0.209
No 946 (98.6) 115 (100)  
Yes 13 (1.4) 0  
GCS on admission    0.003
15 588 (61.4) 54 (47)  
< 15 369 (38.6) 61 (53)  
CSF QCC (log10CFU/mL) 4.58 (2.9–5.4) 0 (0–6.6) 0.053
In-patient data
Number of administered drugs 7 (5–9) 3 (2–4) <.001
Days of stay in hospital 16 (11–19) 8 (4.5–13) <.001
  1. Number of administered drugs, days in hospital, CD4, CSF QCC = median (25th -75th percentile)
  2. Category of age, gender, diagnoses and GCS
  3. CSF Cerebral Spinal Fluid, QCC Quantitative Cryptococcal Culture, CFU Colony Forming Units – for patients presenting with suspected cryptococcal meningitis and for whom CSF culture was collected and quantified (N = 947 with at least one DDI; N = 112 with no DDI)
  4. * t test of means for continuous variables and chi-square for categorical variables with significance at p < .05