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Table 1 Baseline study characteristics

From: Point-of-care thrombocyte function testing using multiple-electrode aggregometry in dengue patients: an explorative study

 

Study population N = 59

Dengue NS1 confirmed n = 10

Dengue probable n = 25

Fever of another origin n = 24

Control group N = 20

p-value

Mean age (range)

28 (14–71)

19 (14–36)

24 (14–54)

35 (14–71)

30 (21–46)

<.05*

Male sex n (%)

30 (50.8%)

3 (30%)

16 (64%)

11 (45.8%)

9 (45%)

.271

Duration of fever days (range)

5.27 (1–30)

3.6 (2–4)

4.6

6.63 (1–30)

N/D

.058

Headache n (%)

39 (66.1%)

9 (90%)

19 (75%)

11 (45.8%)

N/D

.018°

Retro-orbital pain

4 (6.8%)

0 (0%)

4 (16%)

0 (0%)

N/D

.054

Nausea, vomiting

50 (84.7%)

8 (80%)

22 (88%)

20 (83%)

N/D

.812

Rash

3 (5.1%)

1 (10%)

1 (4%)

1 (4.2%)

N/D

.740

Swollen glands

2 (3.3%)

1 (10%)

0 (0%)

1 (4.2%)

N/D

.324

Aches and pains

18 (30.5%)

2 (20%)

9 (36%)

7 (29.2%)

N/D

.639

Mean MAP° (range)

90 (67–125)

89 (76–107)

97 (67–121)

92 (69–125)

N/D

.689

Mean temperature (range)

38.3 (36.0–40.0)

38.3 (36.8–39.4)

38.4 (36.6–39.7)

38.3 (36.0–40.0)

N/D

.962

Mean leukocyte count (range)

7.27 (1.24–22.94)

3.24 (1.24–6.17)

5.56 (1.88–8.90)

10.7 (3.72–22.94)

N/D

<.05*

Mean thrombocyte count (range)

205 (101–815)

156 (101–196)

150 (111–210)

284 (123–815)

N/D

<.05*

Leukocytosis

13 (22.0%)

0 (0%)

0 (0%)

13 (54.2%)

N/D

<.05*

Leucopenia

13 (22.0%)

8 (80%)

5 (20%)

0 (0%)

N/D

<.05*

Thrombocytosis

4 (6.8%)

0 (0%)

0 (0%)

4 (16.7%)

N/D

.044*

Thrombopenia

24 (40.7%)

4 (40%)

14 (56%)

6 (25.0%)

N/A

.087

Increased creatinine+ n/N (%)

2/38 (5.2%)

0/6 (0%)

2/21 (9.5%)

0/11 (0%)

N/D

N/C

X-ray suspected pneumonia n/N (%)

3/15

N/D

0/3 (0%)

3/12 (25%)

N/D

N/C

Urine dipstick/culture positive n/N (%)

7/11 (63%)

1/1 (100%)

0/4 (0%)

6/6 (100%)

N/D

N/C

Blood culture positive n/N (%)

1/1

N/D

N/D

1/1 (100%)

N/D

N/C

Duration of hospital stay in days (range)

2.05 (0–8)

2.50 (1–4)

1.80 (1–4)

2.13 (0–8)

N/D

N/C

  1. Patients with fever on admission were scored for anamnestic parameters according to the WHO dengue 2009 guideline. Cases that were not NS1-confirmed were considered probable dengue on condition that at least two of the following symptoms were presented: headache, retro-orbital pain, muscular/joint pain, nausea/vomiting, swollen glands, rash, leukopenia. Continuous and semi-continuous data was analysed using the Kruskal-Wallis test and categorical data was analysed using the Chi-Squared test. Leukopenia defined as leukocyte count < 3.6 × 109/L; Leukocytosis defined as leukocyte count > 11.0 × 109/L; Thrombocytopenia defined as thrombocyte count < 150 × 109/L; Thrombocytosis defined as thrombocyte count > 400 × 109/L N/D not done; N/C not calculated (for limited data); In case of incomplete data, data is shown as number/Number evaluated (n/N); * significant (p < .05); ° Mean Arterial Pressure; +incomplete data for 21 cases
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BMC Infectious Diseases

ISSN: 1471-2334

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