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Table 1 Baseline study characteristics

From: Point-of-care thrombocyte function testing using multiple-electrode aggregometry in dengue patients: an explorative study

  Study population N = 59 Dengue NS1 confirmed n = 10 Dengue probable n = 25 Fever of another origin n = 24 Control group N = 20 p-value
Mean age (range) 28 (14–71) 19 (14–36) 24 (14–54) 35 (14–71) 30 (21–46) <.05*
Male sex n (%) 30 (50.8%) 3 (30%) 16 (64%) 11 (45.8%) 9 (45%) .271
Duration of fever days (range) 5.27 (1–30) 3.6 (2–4) 4.6 6.63 (1–30) N/D .058
Headache n (%) 39 (66.1%) 9 (90%) 19 (75%) 11 (45.8%) N/D .018°
Retro-orbital pain 4 (6.8%) 0 (0%) 4 (16%) 0 (0%) N/D .054
Nausea, vomiting 50 (84.7%) 8 (80%) 22 (88%) 20 (83%) N/D .812
Rash 3 (5.1%) 1 (10%) 1 (4%) 1 (4.2%) N/D .740
Swollen glands 2 (3.3%) 1 (10%) 0 (0%) 1 (4.2%) N/D .324
Aches and pains 18 (30.5%) 2 (20%) 9 (36%) 7 (29.2%) N/D .639
Mean MAP° (range) 90 (67–125) 89 (76–107) 97 (67–121) 92 (69–125) N/D .689
Mean temperature (range) 38.3 (36.0–40.0) 38.3 (36.8–39.4) 38.4 (36.6–39.7) 38.3 (36.0–40.0) N/D .962
Mean leukocyte count (range) 7.27 (1.24–22.94) 3.24 (1.24–6.17) 5.56 (1.88–8.90) 10.7 (3.72–22.94) N/D <.05*
Mean thrombocyte count (range) 205 (101–815) 156 (101–196) 150 (111–210) 284 (123–815) N/D <.05*
Leukocytosis 13 (22.0%) 0 (0%) 0 (0%) 13 (54.2%) N/D <.05*
Leucopenia 13 (22.0%) 8 (80%) 5 (20%) 0 (0%) N/D <.05*
Thrombocytosis 4 (6.8%) 0 (0%) 0 (0%) 4 (16.7%) N/D .044*
Thrombopenia 24 (40.7%) 4 (40%) 14 (56%) 6 (25.0%) N/A .087
Increased creatinine+ n/N (%) 2/38 (5.2%) 0/6 (0%) 2/21 (9.5%) 0/11 (0%) N/D N/C
X-ray suspected pneumonia n/N (%) 3/15 N/D 0/3 (0%) 3/12 (25%) N/D N/C
Urine dipstick/culture positive n/N (%) 7/11 (63%) 1/1 (100%) 0/4 (0%) 6/6 (100%) N/D N/C
Blood culture positive n/N (%) 1/1 N/D N/D 1/1 (100%) N/D N/C
Duration of hospital stay in days (range) 2.05 (0–8) 2.50 (1–4) 1.80 (1–4) 2.13 (0–8) N/D N/C
  1. Patients with fever on admission were scored for anamnestic parameters according to the WHO dengue 2009 guideline. Cases that were not NS1-confirmed were considered probable dengue on condition that at least two of the following symptoms were presented: headache, retro-orbital pain, muscular/joint pain, nausea/vomiting, swollen glands, rash, leukopenia. Continuous and semi-continuous data was analysed using the Kruskal-Wallis test and categorical data was analysed using the Chi-Squared test. Leukopenia defined as leukocyte count < 3.6 × 109/L; Leukocytosis defined as leukocyte count > 11.0 × 109/L; Thrombocytopenia defined as thrombocyte count < 150 × 109/L; Thrombocytosis defined as thrombocyte count > 400 × 109/L N/D not done; N/C not calculated (for limited data); In case of incomplete data, data is shown as number/Number evaluated (n/N); * significant (p < .05); ° Mean Arterial Pressure; +incomplete data for 21 cases