|
Variable
|
Seropositive cases
|
Seronegative patients
|
|---|
|
Total, n
|
626
|
2129
|
|
Female, n (%)
|
297 (47.4)
|
1253 (58.8)
|
|
Age, mean ± SE (range)a
|
42.9 ± 0.76 (< 1–89)
|
43.0 ± 0.40 (< 1–90)
|
|
Sera samples/patient, mean ± SE (range)b
|
1.3 ± 0.026 (1–7)
|
1.1 ± 0.0067 (1–4)
|
|
Year of onset, n
|
|
2013
|
41
|
276
|
|
2014
|
49
|
279
|
|
2015
|
69
|
275
|
|
2016
|
76
|
413
|
|
2017
|
164
|
465
|
|
2018
|
227
|
421
|
|
Signs and symptoms, n (%)c
|
|
None reported
|
387 (61.8)
|
1361 (63.9)
|
|
Headache
|
134 (54.0)
|
263 (33.1)
|
|
Fever
|
75 (30.2)
|
253 (31.8)
|
|
Fatigue
|
65 (26.2)
|
225 (28.3)
|
|
Gastrointestinal complaints
|
27 (10.9)
|
86 (10.8)
|
|
Respiratory complaints
|
21 (8.5)
|
59 (7.4)
|
|
Arthralgia/arthritis
|
19 (7.7)
|
65 (8.2)
|
|
Rash (maculopapular)
|
15 (6.0)
|
79 (9.9)
|
|
Rash (not described)
|
13 (5.2)
|
51 (6.4)
|
|
Tick bite
|
13 (5.2)
|
46 (5.8)
|
|
Encephalitis/meningitis
|
12 (4.8)
|
23 (2.9)
|
|
Rash (vesicular)
|
10 (4.0)
|
27 (3.4)
|
|
Malaise/unwell
|
9 (3.6)
|
5 (0.6)
|
|
Myalgia/body aches
|
7 (2.8)
|
10 (1.3)
|
|
Chills
|
2 (0.8)
|
8 (1.0)
|
|
Elevated liver enzymes
|
2 (0.8)
|
7 (0.9)
|
|
Jaundice
|
2 (0.8)
|
5 (0.6)
|
|
Anemia
|
1 (0.4)
|
2 (0.3)
|
|
Anxiety
|
1 (0.4)
|
2 (0.3)
|
|
Dizziness
|
1 (0.4)
|
5 (0.6)
|
|
Confusion
|
0 (0.0)
|
2 (0.3)
|
|
Hepatitis
|
0 (0.0)
|
2 (0.3)
|
|
Edema
|
0 (0.0)
|
1 (0.1)
|
- Abbreviations: n/a not applicable
- a Sex of some patients was not available
- bt = 7.3, df = 706, p < 0.0001
- c Cases and patients reporting at least one sign or symptom: seropositive, n = 239; seronegative, n = 768. Some cases and patients have > 1 sign or symptom. Denominator is based on number of cases or patients with at least one symptom reported on the requisition
