Table 3 Factors associated with CD8+ T cells secreting cytokines in the univariate and multivariate linear regression analysis
Variable | CD8_IFN-γ | CD8_TNF-α | CD8_IL-2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | Univariate (raw effects) | Multivariate (adjusted effects) | |||||||
B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | B (95% CI) | P | Adjusted B (95% CI) | Adjusted P | |
Age (≥ 25 vs <  25 years) | 8.08 (1.79, 14.36) | 0.012 | 6.92 (0.41, 13.43) | 0.037 | 8.2 (1.04, 15.37) | 0.025 | 6.89 (−0.59, 14.37) | 0.071 | 0.11 (− 0.36, 0.58) | 0.635 | 0.09 (− 0.42, 0.59) | 0.729 |
Gender (Male ve Female) | 5.25 (−0.69, 11.2) | 0.083 | 3.36 (−2.7, 9.41) | 0.275 | 5.41 (− 1.35, 12.17) | 0.116 | 3.81 (−3.15, 10.77) | 0.281 | 0.22 (−0.22, 0.65) | 0.334 | 0.13 (−0.34, 0.6) | 0.586 |
Family History (Yes vs No) | −1.42 (−6.86, 4.02) | 0.607 | −3.27 (−9.39, 2.86) | 0.293 | −0.56 (− 6.75, 5.62) | 0.858 | −2.22 (− 9.26, 4.82) | 0.534 | 0.01 (− 0.38, 0.41) | 0.943 | −0.03 (− 0.5, 0.44) | 0.903 |
Vertical Transmission (Yes vs No) | −0.84 (−8.24, 6.57) | 0.824 | 1.82 (− 6.43, 10.08) | 0.663 | − 0.85 (− 9.26, 7.55) | 0.841 | 0.72 (− 8.77, 10.2) | 0.881 | − 0.01 (− 0.56, 0.53) | 0.961 | −0.03 (− 0.67, 0.61) | 0.931 |
Infection Time (≥ 20 vs <  20 years) | 4.76 (− 2.88, 12.4) | 0.220 | 0.97 (− 7, 8.94) | 0.810 | 6.1 (− 2.56, 14.75) | 0.166 | 2.69 (− 6.47, 11.86) | 0.562 | − 0.08 (− 0.65, 0.48) | 0.769 | − 0.16 (− 0.77, 0.46) | 0.616 |
Log HBsAg | − 0.021 (− 0.033, − 0.009) | 0.001 | −0.2 (− 4.62, 4.23) | 0.931 | 0.54 (− 4, 37, 5.44) | 0.829 | 0.98 (− 4.11, 6.07) | 0.704 | 0.08 (− 0.24, 0.40) | 0.621 | 0.01 (− 0.33, 0.36) | 0.938 |
Log HBV DNA | −0.054 (− 0.087, − 0.021) | 0.001 | −2.08 (− 4.35, 0.2) | 0.073 | −0.12 (− 1.37, 1.12) | 0.849 | −1.59 (− 4.2, 1.03) | 0.232 | 0.26 (− 0.2, 0.72) | 0.260 | − 0.06 (− 0.24, 0.11) | 0.483 |
HBeAg (Positive vs Negative) | −2.35 (− 7.78, 3.08) | 0.394 | 3.87 (− 5.24, 12.97) | 0.402 | − 1.37 (− 7.54, 4.81) | 0.662 | 2.98 (−7.48, 13.45) | 0.574 | − 0.22 (− 0.62, 0.17) | 0.266 | − 0.01 (− 0.72, 0.69) | 0.969 |
ALT (<  2 ULN is the reference group) | ||||||||||||
 ≥ 2 & < 5 ULN | 10.78 (3.81, 17.75) | 0.003 | 12.5 (4.87, 20.13) | 0.002 | 12.08 (4.18, 19.99) | 0.003 | 13.05 (4.29, 21.82) | 0.004 | −0.14 (− 0.67, 0.38) | 0.594 | − 0.05 (− 0.64, 0.54) | 0.859 |
 ≥ 5ULN | 2.77 (−5.9, 11.45) | 0.528 | 4.93 (−4.61, 14.48) | 0.309 | 5.47 (− 4.38, 15.31) | 0.274 | 6.68 (−4.29, 17.65) | 0.230 | 0.20 (−0.45, 0.86) | 0.539 | 0.23 (−0.51, 0.97) | 0.533 |
Genotype (Genotype C is the reference group) | ||||||||||||
 B | −3.57 (−10.39, 3.24) | 0.302 | −2.42 (−9.2, 4.36) | 0.481 | −6.27 (−16.8, 4.25) | 0.240 | − 3.21 (− 11, 4.58) | 0.417 | −0.52 (− 1.02, − 0.03) | 0.039 | − 0.49 (− 1.02, 0.03) | 0.067 |
 N | − 3.71 (− 12.99, 5.56) | 0.430 | − 10.05 (− 21.31, 1.22) | 0.080 | −8.65 (− 21.77, 4.47) | 0.195 | −10.2 (− 23.15, 2.74) | 0.121 | − 0.36 (− 1.04, 0.31) | 0.288 | −0.59 (− 1.46, 0.28) | 0.184 |
 O | − 8.44 (− 20.01, 3.13) | 0.152 | −7.3 (− 18.92, 4.32) | 0.216 | − 4.83 (− 12.56, 2.9) | 0.219 | − 6.66 (− 20.01, 6.7) | 0.326 | − 0.68 (− 1.52, 0.16) | 0.113 | − 0.64 (− 1.54, 0.26) | 0.161 |