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Table 1 Quantification of inflammatory mediators in cerebella of infected mice

From: Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy

Group a

Analyte (pg/ml) b

TNF-α

IL-1β

IL-6

IL-10

MIP-1β

MCP-1

IP-10

KC

TIMP-1

Saline

4.2 ± 2.5

287 ± 48

1283 ± 1261

10.5 ± 7.1

478 ± 260

4317 ± 4082

357 ± 208

1991 ± 1312

39,689 ± 22,705

CRO

1.5 * ± 0.8

246 ± 66

100 ± 107

2.5 ** ± 2

132 ± 108

777 ± 1130

227 ± 144

478 ± 196

21,273 ± 12,715

CRO + DOX

2.7 ± 1.5

249 ± 70

1182 ± 1273

3.9 ± 1.6

510 ± 370

4322 ± 4373

687 ± 572

2218 ± 2426

25,617 ± 10,617

  1. aMice were divided in 3 groups based on treatment: saline (control), CRO or CRO + DOX
  2. brefer to the results of statistical analysis
  3. */**, statistically significant differences compared to control mice (saline); *, p < 0.05; **, p < 0.01
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BMC Infectious Diseases

ISSN: 1471-2334

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