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Table 1 Quantification of inflammatory mediators in cerebella of infected mice

From: Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy

Group a Analyte (pg/ml) b
TNF-α IL-1β IL-6 IL-10 MIP-1β MCP-1 IP-10 KC TIMP-1
Saline 4.2 ± 2.5 287 ± 48 1283 ± 1261 10.5 ± 7.1 478 ± 260 4317 ± 4082 357 ± 208 1991 ± 1312 39,689 ± 22,705
CRO 1.5 * ± 0.8 246 ± 66 100 ± 107 2.5 ** ± 2 132 ± 108 777 ± 1130 227 ± 144 478 ± 196 21,273 ± 12,715
CRO + DOX 2.7 ± 1.5 249 ± 70 1182 ± 1273 3.9 ± 1.6 510 ± 370 4322 ± 4373 687 ± 572 2218 ± 2426 25,617 ± 10,617
  1. aMice were divided in 3 groups based on treatment: saline (control), CRO or CRO + DOX
  2. brefer to the results of statistical analysis
  3. */**, statistically significant differences compared to control mice (saline); *, p < 0.05; **, p < 0.01
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