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Table 1 Multivariate analysis of the characteristics associated with the presence of TB-IRIS

From: Prevalence and risk factors of paradoxical tuberculosis associated immune reconstitution inflammatory syndrome among HIV-infected patients in Beijing, China

Characteristics TB-IRIS (45) Non-TB-IRIS (154) Total (199) Crude ORb P value Adjusted ORc P value
N (%) N (%) N (%) (95% CI) (95% CI)
Gender
 Male 42 (93.3) 146 (94.8) 188 (94.5) 1 Ref.   
 Female 3 (6.7) 8 (5.2) 11 (5.5) 1.304 (0.331–5.133) 0.705   
Age group (years)
  < 25 9 (20.0) 16 (10.4) 25 (12.6) 1.744 (0.699–4.351) 0.233 2.024 (0.786–5.212) 0.144
 25–44 30 (66.7) 93 (60.4) 123 (61.8) 1 Ref. 1 Ref.
 45–64 5 (11.1) 42 (27.3) 47 (23.6) 0.369 (0.134–1.018) 0.054 0.355 (0.127–0.993) 0.049
  > 64 1 (2.2) 3 (1.9) 4 (2.0) 1.033 (0.104–10.310) 0.978 1.603 (0.156–16.479) 0.692
Initial CD4 cell count (cells/mm3)
  > 100 2 (4.4) 24 (15.6) 26 (13.1) 1 Ref.   
 50–100 3 (6.7) 25 (16.2) 28 (14.1) 1.440 (0.221–9.388) 0.703   
  < 50 40 (88.9) 105 (68.2) 145 (72.9) 4.571 (1.033–20.238) 0.045   
CD4 cell count after ART (cells/mm3)
  > 100 21 (46.7) 71 (46.1) 92 (46.2) 1 Ref.   
 50–100 16 (35.6) 42 (27.3) 58 (29.1) 1.288 (0.606–2.738) 0.511   
  < 50 8 (17.8) 41 (26.6) 49 (24.6) 0.660 (0.268–1.623) 0.365   
Increase in CD4 cell count
  < 4 folds 21 (46.7) 103 (66.9) 124 (62.3) 1 Ref. 1 Ref.
  ≥ 4 folds 24 (53.3) 51 (33.1) 75 (37.7) 2.308 (1.175–4.533) 0.015 2.614 (1.288–5.303) 0.008
HIV virial load (copies/mL)
  ≤ 1000 copies 24 (53.3) 94 (61.0) 118 (59.3) 1 Ref.   
  > 1000 copies 21 (46.7) 60 (39.0) 81 (40.7) 1.371 (0.702–2.677) 0.356   
HAART regimena
 First-line 38 (84.4) 136 (88.3) 174 (87.4) 1 Ref.   
 Second-line 7 (15.6) 18 (11.7) 25 (12.6) 1.392 (0.541–3.578) 0.493   
  1. aFirst-line regimen includes tenofovir, lamivudine and efavirenz; Second-line regimen includes tenofovir, lamivudine and lopinavir/ritonavir
  2. bOR, odds ratio; CI, confidential interval
  3. cThe initial CD4 cell count is considered as a confounding variable of increase in CD4 cell count, which is removed in the multivariate analysis