Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya

Table 3 Influence of glucose-6-phosphate dehydrogenase on P. falciparum malaria infection in children under 3 years in Vihiga County, Kenya

Category	Prevalence (%)	SMA n = 137	Non-SMA n = 437	P-Value^a	OR	95% CI	P-Value^b
G6PD deficiency					SMA
Normal	360 (62.7)	77 (56.2)	283 (64.8)	0.040	Ref	–	–
Intermediate	201 (35.0)	59 (43.1)	142 (32.5)		1.527	1.029–2.266	0.035
Deficient	13 (2.3)	1 (0.7)	12 (2.7)		0.306	0.039–2.392	0.259

Prevalence in the G6PD genotypes in population studied are presented as n (percentage, %). Data shown are number (n) and proportions (%) of subjects. Odds ratios (OR) and 95% confidence intervals (95% CI) were determined using multivariate logistic regression controlling for age and sex. Non-severe malaria anaemia was used as the reference category. G6PD, glucose-6-phosphate dehydrogenase. Normal, normal G6PD. Intermediate, heterozygous G6PD. Deficient, homozygous G6PD. SMA, severe malaria aneamia; Non-SMA, non-severe malaria anaemia

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