Table 3 Antimicrobial resistance determinants of clinical S. Typhimurium isolates resistant to both ciprofloxacin and cephalosporins
Strain | Years | STs | QRDR mutations | PMQR genes | β-Lactamase genes and types | Macrolide resistance gene | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
gyrA | parC | qnrS | aac(6′)-Ib-cr | blaCTX-M | blaOXA | blaCMY-2 | blaTEM-1 | mphA | |||
Sal0475 | 2006 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | blaCTX-55 | blaOXA-1 | blaCMY-2 | – | – |
Sal0485 | 2006 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | blaCTX-15 | blaOXA-1 | – | – | – |
Sal0490 | 2007 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | blaCTX-55 | blaOXA-1 | – | – | – |
Sal0496 | 2007 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | blaCTX-55 | blaOXA-1 | – | – | – |
Sal0507 | 2008 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | blaCTX-15 | blaOXA-1 | – | – | – |
Sal0515 | 2008 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | aac(6′)-Ib-cr | blaCTX-55 | blaOXA-1 | – | blaTEM-1 | mphA |
Sal0525 | 2009 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | – | blaOXA-1 | – | – | – |
Sal0616 | 2010 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | blaCTX-14 | blaOXA-1 | – | – | – |
Sal0552 | 2010 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | – | – | blaCTX-14 | blaOXA-1 | – | – | – |
Sal0553 | 2010 | 19 | Asp87Tyr | WT | – | – | – | blaOXA-1 | – | – | mphA |
Sal0572 | 2011 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | qnrS1 | – | blaCTX-55 | blaOXA-1 | – | – | – |
Sal0619 | 2012 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | qnrS1 | aac(6′)-Ib-cr | blaCTX-55 | blaOXA-1 | – | – | – |
Sal0592 | 2013 | 19 | Ser83Phe, Asp87Asn | Ser80Arg | qnrS1 | – | – | blaOXA-1 | – | – | – |