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Table 5 Relationship of CD4+ T cell count in HIV-pleural TB co-infected (n = 22,CD4+ T cell count not available for four patients), and the mycobacterial DNA load in all nested-PCR positive patients (n = 18) with AFB microscopy, culture and the mycobacterial antigens by Pearson chi-square test

From: Mycobacterial antigens in pleural fluid mononuclear cells to diagnose pleural tuberculosis in HIV co-infected patients

 

CD4 > 100

CD4 < 100

p-value

DNA lowa

DNA higha

p-value

culture+

2

9

0.07

2

8

0.06

culture-

6

5

 

5

3

 

Microscopy +

0

3

0.15

0

4

0.07

Microscopy -

8

11

 

7

7

 

Cell wall antigen+

0

9

0.003

0

7

0.007

Cell wall antigen-

8

5

 

7

4

 

Heterogeneous antigens+

2

8

0.14

4

5

0.62

Heterogeneous antigens-

6

6

 

3

6

 

LAM+

3

8

0.37

4

5

0.62

LAM-

3

6

 

3

6

 

secreted antigen+

1

8

0.04

2

5

0.47

secreted antigen-

7

6

 

5

6

 

N-PCR+

3

9

0.22

   

N-PCR-

5

5

    

RT-PCR+

0

2

0.26

0

2

0.23

RT-PCR-

8

12

 

7

9

 
  1. N-PCR Nested PCR, RT-PCR Real time PCR
  2. aDNA load is based on the number of positives among triplets from each case, low = 1/3, high = 3/3 positive
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BMC Infectious Diseases

ISSN: 1471-2334

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