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Table 1 Clinical characteristics, drug resistance genes and virulence-associated genes of 44 CRKP isolates

From: Outbreak of KPC-2 Carbapenem-resistant Klebsiella pneumoniae ST76 and Carbapenem-resistant K2 Hypervirulent Klebsiella pneumoniae ST375 strains in Northeast China: molecular and virulent characteristics

Isolate no. Age (yr) Date of specimen collection (yr/mo/day) Isolation site(s) Ward Underlying disease Treatment Outcome Resistance genes Virulence genes MLST
JmsCRE01 45–50 2015/3./11 Sputum ICU Brain and abdominal injury, pneumonia Cefmenoxime, ETP, IMP, SCF, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE02 55–60 2016/12/29 Sputum Neurosurgery Brain injury, bacteremia, pneumonia TZP, CRO, LZD, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE03 75–80 2016/11/21 Sputum ICU Lung cancer, cerebral hemorrhage, pneumonia TZP, IMP, SCF, LVX Died KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE04 55–60 2016/6/18 Sputum Neurosurgery Cerebral hemorrhage, pneumonia TZP, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE05 65–70 2016/8/2 Sputum Neurosurgery Brain injury, cerebral hemorrhage, pneumonia TZP, LVX, Cefoselis Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE06 65–70 2017/1/13 Sputum Hematology Cerebral hemorrhage, pneumonia, hypertension TZP Died KPC-2, SHV uge, mrkD, fimH, kpn 323
JmsCRE07 15–20 2016/8/22 Sputum Emergency department Brain injury, hemorrhagic shock, pleural effusion, pneumonia Cefoperazone/tazobactam, IMP Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE08 70–75 2016/11/9 Sputum Neurosurgery Cerebral hemorrhage, hypertension, pneumonia, pleural effusion TZP, CTT, MXF Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE09 85–90 2016/8/22 Sputum ICU Intestinal obstruction, liver abscess, lung space, pneumonia Cefoperazone/tazobactam, IMP Died KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE10 75–80 2016/11/2 Sputum ICU Cerebral hemorrhage, pneumonia Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE11 60–65 2016/11/2 Sputum Neurosurgery Cerebral hemorrhage, pneumonia, hypertension TZP, SCF Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE12 75–80 2016/8/29 Sputum ICU Cerebral infarction, pericardial effusion, pneumonia Cefoperazone/tazobactam, VAN, LVX Died KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE14 60–65 2016/11/14 Sputum Neurosurgery Cerebral hemorrhage TZ, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE15 30–35 2016/11/9 Sputum Orthopedics Cervical fracture, pneumonia CLI, TZP, IMP, SCF, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE16 55–60 2016/6/8 Sputum ICU Cerebral hemorrhage, pleural effusion, pneumonia CTT, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE17 80–85 2016/9/8 Sputum ICU Infectious shock, pneumonia TZP, IMP, MXF Died KPC-2, SHV, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE18 40–45 2016/4/11 Sputum ICU Brain palsy, brain injury TZP, LVX Died KPC-2, SHV, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE20 55–60 2016/5/10 Sputum Neurosurgery Aneurysm, cerebral hemorrhage TZP, Ceftezole Died KPC-2, SHV, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE22 55–60 2017/2/5 Sputum Emergency department Gastric cancer, pneumonia CMZ, TZP, SCF, MXF Died IMP-4, SHV, TEM uge, mrkD, fimH, kpn 896
JmsCRE23 55–60 2016/8/22 Blood ICU Brain injury, cerebral hemorrhage, peritoneal effusion, TZP, SCF, IMP NR KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE24 65–70 2016/7/27 Blood Neurosurgery Cerebral hemorrhage, bacteremia, pneumonia, diabetes CMZ, TZP, AMK, SCF Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE28 25–30 2016/10/25 Blood ICU Abdominal closure injury, spleen rupture, peritoneal effusion TZP, IMP Died KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE29 40–45 2016/8/12 Sputum Neurosurgery Cerebral hemorrhage, pneumonia CMZ, TZP Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE30 65–70 2016/7/28 Sputum ICU Hydronephrosis, bacteremia, pneumonia LVX, MXF, IMP, SCF, MSU Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE31 55–60 2016/5/27 Sputum Neurosurgery Brain abscess, pneumonia Cefoselis, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge 76
JmsCRE32 35–40 2015/10/30 Sputum Neurosurgery Brain injury TZP, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE34 60–65 2016/7/14 Sputum ICU Renal failure, uremia, cerebral infarction, pneumonia, pleural effusion TZP Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE35 70–75 2016/7/22 Sputum Neurosurgery Cerebral hemorrhage, cerebral infarction, pneumonia TZP, MXF Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE36 70–75 2016/8/28 Wound ICU Lower extremity crush sleeve, femoral shaft fracture TZP, SCF, LVX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE37 55–60 2015/12/23 Sputum Hematology Myelodysplastic syndrome, bacteremia MEM, TZP Died IMP-4, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 2964
JmsCRE39 70–75 2016/11/30 Sputum Neurosurgery Cerebral infarction, coronary heart disease, pneumonia, Intracranial infection TZP, FOX Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE44 65–70 2016/4/29 Sputum Neurosurgery Intracranial occupying lesions, pneumonia CFZ, TZP Died KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE47 55–60 2016/9/30 Blood Hematology Aplastic anemia, bacteremia FOX, Cefoperazone/tazobactam, MXF, MEM Recovered KPC-2, SHV uge, mrkD, fimH, kpn 11
JmsCRE48 75–80 2017/4/28 Sputum Neurosurgery Brain palsy, Cerebral hemorrhage, pneumonia Ceftezole, TZP, MXF Died KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE49 55–60 2017/6/7 Blood Cardiac surgery Brain injury, cerebral hemorrhage, pneumonia, bacteremia TZP, SCF, Etimicin, FOF, IMP, LVX, AMK Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE50 75–80 2017/4/14 Sputum Neurosurgery Cerebral infarction, pneumonia, hypertension TZP, FEP, LVX, IMP, SCF, MXF Recovered KPC-2, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE52 45–50 2016/10/6 Sputum ICU Brain injury, intracranial infection ATM, CRO, Cefoselis, LZD Recovered KPC-2, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE54 65–70 2016/4/6 Sputum Neurosurgery Cerebral infarction, urinary tract infection, pneumonia TZP, MXF Recovered KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE55 55–60 2017/4/7 Sputum ICU Cerebral hemorrhage, pneumonia TZP, MEM NR KPC-2, SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE56 60–65 2017/9/3 Sputum Neurosurgery Cerebral hemorrhage, pneumonia, bronchiectasis TZP Recovered SHV, TEM, CTX-M-15 uge, mrkD, fimH, kpn 76
JmsCRE57 70–75 2017/11/8 Sputum ICU Subarachnoid hemorrhage, cerebral aneurysm, hypostatic pneumonia, hypertension, arrhythmia Cefoselis, CRO, FOF, Etimicin Recovered KPC-2, SHV, DHA, TEM, CTX-M-15 uge, mrkD, fimH, kpn, aero, rmpA 375
JmsCRE58 40–45 2017/10/14 Sputum ICU Brain injury, subarachnoid hemorrhage, skull fracture, chest closure injury, rib fracture TZP, LVX, Etimicin, VRC Recovered IMP-4, SHV, TEM uge, mrkD, fimH, kpn 76
JmsCRE59 55–60 2018/1/16 Sputum Emergency department Cerebral infarction, pneumonia, hypertension CMZ, Etimicin Recovered NDM, TEM, CTX-M-15 uge, mrkD, fimH, kpn 530
JmsCRE62 35–40 2017/12/13 Sputum Emergency department Diabetes ketoacidosis, ion disorder, urinary tract infection, pneumonia, hypoproteinemia, anemia Cefoperazone/tazobactam, Etimicin Recovered KPC-2, SHV, DHA, TEM, CTX-M-15 uge, mrkD, fimH, kpn, alls 3335
  1. Note: ICU Intensive Care Unit, ETP ertapenem, IMP imipenem, SCF cefoperazone/sulbactam, LVX levofloxacin, TZP piperacillin/tazobactam, CRO ceftriaxone, LZD linezolid, CTT cefotetan, MXF moxifloxacin, VAN vancomycin, CLI clindamycin, CMZ cefmetazole, AMK amikacin, MSU mezlocillin/sulbactam, CFZ cefazolin, FOX cefoxitin, MEM meropenem, FOF fosfomycin, FEP cefepime, ATM aztreonam, VRC voriconazole; −,unmedicated, NR no record, MLST multilocus sequence typing. Resistance and virulence genes were amplified by PCR.
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