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Table 3 Risk factors for in-hospital mortality

From: Risk factors for and clinical outcomes of carbapenem non-susceptible gram negative bacilli bacteremia in patients with acute myelogenous leukemia

VariablesSurvival (N = 426)In-hospital mortality (N = 63)UnivariateMultivariate
OR (95%CI)PaOR (95%CI)P
Age, mean (± SD)50.9 (± 14.8)55.4 (± 14.2)1.0 (1.0–1.0)0.025
Male250 (58.7)33 (52.4)0.8 (0.5–1.3)0.344
Chemotherapy
 Induction or re-induction158 (37.1)45 (71.4)4.2 (2.4–7.6)< 0.0013.5 (1.7–7.0)0.001
 Consolidation268 (62.9)18 (28.6)
Diabetes mellitus113 (26.5)23 (36.5)1.6 (0.9–2.8)0.099
Isolation of resistant organism in the prior 1 year
 VRE27 (6.3)17 (27.0)5.5 (2.8–10.8)< 0.0014.3 (1.8–10.2)0.001
 ESBL21 (4.9)8 (12.7)2.8 (1.2–6.6)0.023
 CRPA8 (1.9)3 (4.8)2.6 (0.7–10.1)0.158
 CRAB4 (0.9)5 (7.9)9.1 (2.4–34.8)0.003
History of GNB bacteremia in the prior 1 year136 (31.9)31 (49.2)2.1 (1.2–3.5)0.007
Presence of preceding bacteremia during the hospitalization42 (9.9)19 (30.2)3.9 (2.1–7.4)< 0.001
Primary foci of infection
 Intra-abdominal infection66 (15.5)6 (9.5)0.6 (0.2–1.4)0.212
 Central line associated infection54 (12.7)6 (9.5)0.7 (0.3–1.8)0.507
 Urinary tract infection7 (1.6)1 (1.6)1.0 (1.1–8.0)1.000
 Pneumonia2 (0.5)4 (6.3)14.4 (2.6–80.2)0.00332.7 (5.1–208.5)< 0.001
 Others9 (2.1)0 (0.0)0.9 (0.8–0.9)0.374
 Unknown288 (67.6)46 (73.0)1.3 (0.7–2.3)0.389
Pitt score, median (IQR)1.3 (0.0–2.0)4.1 (1.0–5.0)1.5 (1.3–1.7)< 0.0011.5 (1.3–1.7)< 0.001
Septic shock73 (17.1)29 (46.0)4.1 (2.4–7.2)< 0.001
Carba-NS24 (5.6)21 (33.3)8.4 (4.3–16.3)< 0.0016.6 (3.0–14.8)< 0.001
Inappropriate empiric antibiotics27 (6.3)13 (20.6)3.8 (1.9–7.9)< 0.001
Hospital stay, median
 Days from chemotherapy to GNB bacteremia, median (IQR)14.2 (11.0–16.0)18.0 (11.0–21.0)1.1 (1.0–1.1)< 0.001
Hospital days to GNB bacteremia, median (IQR)21.2 (14.0–20.0)40.3 (18.0–61.0)1.0 (1.0–1.1)< 0.001
  1. OR odds ratio, aOR adjusted odds ratio, CI confidence interval, SD standard deviation, VRE vancomycin resistant enterococci, ESBL extended-spectrum β-lactamase-producing enterobacteriaceae, CRPA carbapenem resistant Pseudomonas aeruginosa, CRAB carbapenem resistant Acinetobacter baumannii, GNB gram negative bacilli, IQR interquartile range, Carba-NS carbapenem non-susceptible