Table 1 Demographic profile and clinical features of culture-confirmed children TBM in Southwest China, 2013–2018 (n = 42)
Variable | Total n = 42 (%) |
|---|---|
Mean age; months (range) | 93(5–168) |
< 1 years | 5(11.9) |
1-5 years | 8(19.0) |
5-14 years | 29(69.0) |
Female | 21(50.0) |
BCG vaccination | 2 (4.8) |
Chinese Ethnic minorities | |
Han | 7(16.7) |
Tibetan | 27(64.3) |
Yi | 6(14.3) |
Qiang | 1(2.4) |
History & Clinical Findings | |
Temperature above 37.5 °C | 38(90.5) |
Headache | 30(71.4) |
Convulsions | 4(9.5) |
Disturbance of consciousness | 14(33.3) |
Cough | 19(45.2) |
Vomiting | 22(52.4) |
Weight loss | 6(14.3) |
Night sweats | 3(7.1) |
Neck stiffness | 35(83.3) |
CSF pressure > 200 mmH2O | 30(71.4) |
Recent close contact with an infectious TB casea | 13(31.0) |
Imaging | |
Chest X-ray suggestive of TB | 42(100.0) |
Basal meningeal enhancement | 12(28.6) |
Cerebral oedema/Hydrocephalus | 7(16.7) |
Outcome | |
Recovery | 35(83.3) |
Sequelae | 6(14.3) |
Death before hospital discharge | 1(2.38) |
Drug-induced Uric acid UA (> 430 μmol / L) | 10(23.8) |
ATD-induced hepatotoxicityb | 6(14.3) |