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Table 1 Mean (SD) of the five most commonly reported cytokines among leptospirosis patients with different outcomes and the controls

From: Cytokine response in human leptospirosis with different clinical outcomes: a systematic review

Study NoYearTypeControlLeptospirosis patientsMild diseaseSevere diseaseSurvivedFatalLiver involvementRenal involvement
nMean (pg/ml)SDnMean (pg/ml)SDnMean (pg/ml)SDnMean (pg/ml)SDnMean (pg/ml)SDnMean (pg/ml)SDnMean (pg/ml)SDnMean (pg/ml)SD
Bandara K2018IL-101218.610.55730.733.2NRNRNRNRNRNRNRNRNRNRNRNR77.99.41411.411.8
  TNF-α1263.037.257700.0619.0NRNRNRNRNRNRNRNRNRNRNRNR7702.8532.314422.5373.1
Fernando N2018IL-6180.10.25139.483.12657.987.72512.813.5NRNRNRNRNRNRNRNRNRNRNRNR
  IL-8180.10.45125.835.22636.235.72517.716.2NRNRNRNRNRNRNRNRNRNRNRNR
  IL-10180.005121.768.72648.078.1250.91.8NRNRNRNRNRNRNRNRNRNRNRNR
Chirathaworn C2016IL-6252.7NRNRNRNR2086.7NR20849.2NRNRNRNRNRNRNRNRNRNRNRNRNR
  IL-82532.5NRNRNRNR201020.0NR202244.5NRNRNRNRNRNRNRNRNRNRNRNRNR
  IL-10254.0NRNRNRNR201020.0NR20234.7NRNRNRNRNRNRNRNRNRNRNRNRNR
  TNF-α257.9NRNRNRNR2058.7NR2011.0NRNRNRNRNRNRNRNRNRNRNRNRNR
Papa A2015IFN-γ20137.1NRNRNRNR7130.2NR47170.4NRNRNRNRNRNRNRNRNRNRNRNRNR
  IL-62010.2NRNRNRNR7111.6NR47190.8NRNRNRNRNRNRNRNRNRNRNRNRNR
  IL-82019.2NRNRNRNR7111.6NR47223.6NRNRNRNRNRNRNRNRNRNRNRNRNR
  IL-102020.4NRNRNRNR730.2NR4743.4NRNRNRNRNRNRNRNRNRNRNRNRNR
  TNF-α2055.2NRNRNRNR782.1NR47124.5NRNRNRNRNRNRNRNRNRNRNRNRNR
Rizvi M2014IL-83053.8NRNRNRNRNRNRNRNRNRNRNRNRNRNRNRNR46176.0NRNRNRNR
  IL-103012.8NRNRNRNRNRNRNRNRNRNRNRNRNRNRNRNR4632.9NRNRNRNR
  TNF-α30167.0NRNRNRNRNRNRNRNRNRNRNRNRNRNRNRNR4646.5NRNRNRNR
Kyriakidis I2011IL-6NRNRNR4446.2NRNRNRNRNRNRNR3944.2NR5105.9NRNRNRNRNRNRNR
  IL-8NRNRNR446.8NRNRNRNRNRNRNR395.5NR52.8NRNRNRNRNRNRNR
  IL-10NRNRNR4447.3NRNRNRNRNRNRNR3919.9NR5214.3NRNRNRNRNRNRNR
  TNF-αNRNRNR4479.9NRNRNRNRNRNRNR39103.4NR519.3NRNRNRNRNRNRNR
  1. N Total, NR Not reported, SD Standard deviation