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Table 4 In vitro antifungal susceptibility of 1539 clinical C. albicans and C. glabrata isolates from VVC and RVVC as determined by the CLSI method

From: Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis

  AmB FLU NYS TEB AFG CFG MFG BUC CLO FLC ITC MIC TEC VRC
C. albicans
 VVC Range 0.15–32 0.030–128 0.03–32 0.03–256 0.008–0.5 0.008–0.5 0.008–0.5 0.015–32 0.015–32 0.06–128 0.015–32 0.015–32 0.015–32 0.015–8
GM 0.21 0.65 1.55 39.23 0.02 0.1 0.03 0.11 0.05 0.74 0.09 0.27 0.12 0.06
MIC90 0.5 4 8 256 0.03 0.25 0.25 1 0.25 4 1 4 2 0.5
 RVVC Range 0.015–32 0.06–128 0.03–32 0.25–256 0.008–0.25 0.008–0.5 0.008–0.5 0.015–8 0.015–16 0.06–64 0.015–32 0.015–32 0.015–32 0.015–8
GM 0.25 0.94 1.82 74.50 0.01 0.1 0.03 0.13 0.05 1.03 0.10 0.46 0.33 0.09
MIC90 0.6 4 8 256 0.015 0.25 0.06 1 0.5 4 0.5 8 8 0.5
P 0.813 0.435 0.770 0 0.242 0.7 0.566 0.736 0.341 0.14 0.041 0.053 0 0.34
C. glabrata
 VVC Range 0.03–2 0.06–16 0.03–32 0.25–256 0.015–0.5 0.008–0.5 0.008–0.5 0.015–16 0.015–16 0.125–128 0.015–32 0.015–16 0.015–32 0.015–32
GM 0.33 0.18 3.88 40.63 0.03 0.06 0.05 0.24 0.23 1.68 0.42 0.25 0.15 0.09
MIC90 1 1 8 256 0.06 0.25 0.25 1 1 8 4 2 1 0.25
 RVVC Range 0.03–2 0.06–2 0.03–16 0.25–256 0.008–0.06 0.008–0.5 0.008–0.5 0.015–8 0.03–4 0.125–128 0.03–32 0.03–32 0.015–32 0.015–32
GM 0.20 0.17 2.31 8.86 0.02 0.06 0.04 0.16 0.134 1.03 0.29 0.27 0.17 0.11
MIC90 0.5 1 8 256 0.03 0.25 0.25 1 1 16 2 4 2 0.5
P 0.017 0.366 0.035 0.015 0.058 0.68 0.78 0.87 0.25 0.1 1 0.043 0.683 0.293
  1. Note: GM geometry mean, BUC butoconazole, CLO Clotrimazole, FLC Fluconazole, ITC Itraconazole, VRC Voriconazole, MIC Miconazole, TEC Terconazole, AmB Amphotericin B, FLU Flucytosine, NYS Nystatin, TEB Terbinafine, AFG Anidulafungin, CFG Caspofungin, MFG Micafungin. The MIC GM value of C. albicans for Itraconazole, Terconazole, and Terbinafine in RVVC is higher than those in VVC. The MIC GM value of C. glabrata for Miconazole, Amphotericin B, Nystatin, Caspofungin, and Terbinafine in RVVC is higher than those in VVC