Phase II trial evaluating the clinical efficacy of cefixime for treatment of active syphilis in non-pregnant women in Brazil (CeBra)

Table 4 Sample size to detect a minimum acceptable efficacy (p₀) of 0.80 using a two-sided Exact binomial test for difference assuming alpha = 5% and power = 80%*

Anticipated efficacy P	Sample size *	Effective sample size (20% inflated) n
0.86	316	395
0.87	225	282
0.88	173	217
0.89	131	164
0.90	107	134
0.91	88	110
0.92	69	87
0.93	55	69
0.94	48	60
0.95	41	52
0.96	34	43
0.97	26	33
0.98	26	33
0.99	17	22

ISSN: 1471-2334