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Table 3 Risk Factors associated with S. aureus infection: Multivariable Cox regression analysis results

From: Burden of Staphylococcus aureus infections after orthopedic surgery in Germany

VariablePatients who experienced a SAI in the 365-day follow-up period (N = 1430) compared to patients who did not experience a SAI (N = 72,897)
 HR95% CIp-value
Age at index1.021.01–1.02p < 0.001
Female sex0.620.56–0.70p < 0.001
Index surgery type
 Hip; N (%)- Reference -  
 Knee; N (%)0.840.73–0.98p = 0.024
 Spine; N (%)0.970.86–1.10p = 0.686
CCI (12 months baseline period)1.131.11–1.15p < 0.001
Length of index hospitalization in days1.021.01–1.02p < 0.001
Complications due to prosthetic devices/ implants/grafts during index hospitalization1.271.05–1.54p = 0.012
Recent fractures at the location of index surgery (3 months baseline period)2.051.81–2.32p < 0.001
Bacterial infections (not caused by any Staphylococci) during index hospitalization1.381.16–1.64p < 0.001
Number of outpatient prescriptions of antibiotics
(12 months baseline period)
1.061.03–1.09p < 0.001
  1. HRs are based on a conducted multivariable Cox regression analysis with time to first S. aureus infection after index surgery as the dependent variable. CCI Charlson Comorbidity Index, S aureus, Staphylococcus aureus, SAI Staphylococcus aureus infection