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Table 2 Comparison of published meta-analyses of Xpert® MTB/RIF for diagnosis of extrapulmonary tuberculosis

From: Xpert MTB/RIF assay for diagnosis of extrapulmonary tuberculosis in children: a systematic review and meta-analysis

Author/YearSearch periodGroups of children includedNumber of studies included in the meta-analysisNumber of specimens includedSpecimen typesAccuracy of Xpert
All samplesLymph node TBTB meningitisPleural TBBone or joint TB
Chang, 2012Up to Oct 1, 2011No classification by age71058Multiple forms combinedSensitivity 80.4%; Specificity 86.1%Not reportedNot reportedNot reportedNot reported
Denkinger, 2014Up to Oct 15, 201310 studies included children184461Lymph node, CSF, Pleural fluidSensitivity 97.4%; Specificity not reportedSensitivity 83%; Specificity 94%Sensitivity 81%; Specificity 98%Sensitivity 46%; Specificity 99%Not reported
Maynard-Smith, 2014Up to Nov 6, 20133 studies enrolled only children, 3 included all age-groups276026Lymph node, CSF, Other formsMedian sensitivity 83% (IQR, 68–94%; median specificity 98% (IQR, 89–94%)Sensitivity 96%;
Specificity 93%
Median sensitivity
85% (IQR, 75–100%);
Median
specificity 100%
(IQR, 98–100%)
Sensitivity 34%;
Specificity 98%
Not reported
Penz, 2015Up to Aug 15, 2014No classification by age369523Lymph node, CSF, Other formsSensitivity 77%; Specificity 97%Sensitivity 87%;
Specificity 92%
Sensitivity 69%;
Specificity 97%
Sensitivity 37%;
Specificity 98%
Not reported
Sehgal, 2016Up to Aug 31, 2015No classification by age242486Pleural fluidPleural fluid samples onlyNot reportedNot reportedSensitivity 51.4%; Specificity 98.6%Not reported
Li S, 2017Up to June 20, 2015No classification by age26Not reportedMultiple forms combinedSensitivity 80%; Specificity 97%Not reportedNot reportedNot reportedNot reported
Kohli, 2018Up to Aug 7, 201730 studies included children6616213Lymph node, CSF, Other formsVaried across different types of specimensSensitivity 87.6%; Specificity 86.0%Sensitivity 71.1%; Specificity 98.0%Sensitivity 50.9%; Specificity 99.2%Sensitivity 97.2% (fluid), 91.8%(tissue); Specificity 90.2% (fluid), 82.0% (tissue)
Yu G, 2019Up to Jul 6, 2018No classification by age211629Lymph nodeLymph node samples onlySensitivity 84%; Specificity 91%Not reportedNot reportedNot reported
Shen Y, 2019Up to May 7, 2019No classification by age141884Bone or joint samplesBone and joint samples onlyNot reportedNot reportedNot reportedSensitivity 82% (pus), 84% (tissue); Specificity 99% (pus), 98% (tissue)
Current studyUp to Jul 16, 2019Only samples taken from children were included8597Lymph node, CSF, Other formsSensitivity 71.3%; Specificity 97.2%Sensitivity 80.2%; Specificity 94.0%Sensitivity 41.7%; Specificity 98.7%Meta-analysis could not be performedMeta-analysis could not be performed
  1. EPTB extrapulmonary tuberculosis, TB tuberculosis, IQR interquartile range, CSF cerebrospinal fluid