Fig. 7

Polarization of microglia/macrophages in S. japonicum egg-induced granulomas in mice. a-d: Immunohistochemical staining illustrating M1 polarization of microglia/macrophages on day 3 in egg-injected mice as indicated by positive iNOS expression (circle) surrounding the eggs (asterisk). e-m: Immunofluorescent staining indicating M2 polarization of microglia/macrophages in egg-injected mice. M2 polarization sustained from day 3 until inflammation subsidence on day 30, as indicated by positive expression of both Arg1 (red) and IBA1 (green). S. japonicum eggs: Asterisk