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Table 3 Univariate regression analysis for risk factors associated with antifungal resistance candidemia

From: Antifungal resistance in patients with Candidaemia: a retrospective cohort study

 Antifungal sensitive
(N = 96)
Antifungal resistance
(N = 26)
OR (95% CI)P value
Age (years)
Mean ± SD
58.7 ± 16.256.5 ± 20.29  
Gender, n (%)
 Male53 (55.21)10 (38.46)0.5 (0.2_1.23)0.12
 Female43 (44.79)16 (61.54)  
Comorbidities, n (%)
 Diabetes61 (63.54%)15 (57.69%)0.94 (0.77_1.15)0.58
 Hypertension56 (58.33%)16 (61.54%)1.02 (0.85_1.23)0.76
 Chronic Kidney disease14 (14.58%)4 (15.38%)1.01 (0.77_1.32)0.91
 Liver Cirrhosis10 (10.42%)4 (15.38%)1.11(0.78_1.57)0.48
 Cardiovascular disease44 (45.83)16 (61.54)1.14(0.94_1.37)0.15
 Lung diseases24 (25%)6 (23.08%)0.97 (0.79_1.2)0.83
 Solid organ transplantation2 (2.08%)2 (7.69%)1.59 (0.59_4.26)0.15
 Hematological malignancy2 (2.08%)0  
 Non Hematological malignancy35 (36.46%)2 (7.69%)0.75 (0.65_0.88)0.004
 Neutropenia7 (7.29%)4 (15.38%)1.09 (0.31_3.79)0.88
 History of IV drug user2 (2.08%)1 (3.85%)1.18 (0.52_2.65)0.6
3-months exposure before candidemia 
Blood/ Platelet transfusion60 (62.5%)20 (76.92%)1.14 (0.95_1.36)0.16
Recent hospital admission20 (20.83%)8 (30.77%)1.13 (0.87_1.45)0.28
Broad spectrum antibiotics90 (93.75%)26 (100%)1.28 (1.16_1.42)0.19
Polyene antifungal3 (3.13)00.78 (0.71_0.85)0.36
Azole antifungal (fluconazole)8 (8.33%)1 (3.85%)0.87 (0.68_1.12)0.43
Echinocandins19 (19.79%)12 (46.15%)1.38 (1.02_1.85)0.006
Corticosteroids52 (54.17%)19 (73.08%)1.17 (0.98_1.4)0.08
TPN13 (13.54%)4 (15.38%)1.03 (0.78_1.36)0.81
Central catheter insertion71 (73.96%)21 (80.77%)1.07 (0.88_1.31)0.47
Urine catheter73 (76.04%)17 (65.38%)0.88 (0.69_1.12)0.27
Invasive Ventilation44 (45.83%)20 (76.92%)1.3 (1.08_1.57)0.005
Previous surgery38 (39.58%)14 (53.85%)1.13 (0.93_1.37)0.19
 GI21(55.26%)4 (28.5%)1.08 (0.88_1.31)0.42
 Non- GI17 (44.7%)10 (71.4%)
Renal Replacement therapy36 (37.5%)12 (46.15%)1.08 (0.88_1.31)0.42
 HD26 (27.08)12 (46.15)1.21 (0.96_1.54)0.06
 PD3 (3.13)0  
 CRRT9 (9.38)0  
 SLID2 (2.08)2 (7.69)1.59 (0.59–4.2)0.15
  1. Odd ratio (OR); Confidence interval (CI); Total parental nutrition (TPN); Gastrointestinal (GI); Hemodialysis (HD); Peritoneal dialysis (PD); Continuous renal replacement therapy (CRRT); Sustained low efficiency dialysis (SLID) N = total number of patients; n = number of patients or events