Table 3 Univariate regression analysis for risk factors associated with antifungal resistance candidemia
From: Antifungal resistance in patients with Candidaemia: a retrospective cohort study
Antifungal sensitive (N = 96) | Antifungal resistance (N = 26) | OR (95% CI) | P value | |
|---|---|---|---|---|
Age (years) Mean ± SD | 58.7 ± 16.2 | 56.5 ± 20.29 | ||
Gender, n (%) | ||||
Male | 53 (55.21) | 10 (38.46) | 0.5 (0.2_1.23) | 0.12 |
Female | 43 (44.79) | 16 (61.54) | ||
Comorbidities, n (%) | ||||
Diabetes | 61 (63.54%) | 15 (57.69%) | 0.94 (0.77_1.15) | 0.58 |
Hypertension | 56 (58.33%) | 16 (61.54%) | 1.02 (0.85_1.23) | 0.76 |
Chronic Kidney disease | 14 (14.58%) | 4 (15.38%) | 1.01 (0.77_1.32) | 0.91 |
Liver Cirrhosis | 10 (10.42%) | 4 (15.38%) | 1.11(0.78_1.57) | 0.48 |
Cardiovascular disease | 44 (45.83) | 16 (61.54) | 1.14(0.94_1.37) | 0.15 |
Lung diseases | 24 (25%) | 6 (23.08%) | 0.97 (0.79_1.2) | 0.83 |
Solid organ transplantation | 2 (2.08%) | 2 (7.69%) | 1.59 (0.59_4.26) | 0.15 |
Hematological malignancy | 2 (2.08%) | 0 | ||
Non Hematological malignancy | 35 (36.46%) | 2 (7.69%) | 0.75 (0.65_0.88) | 0.004 |
Neutropenia | 7 (7.29%) | 4 (15.38%) | 1.09 (0.31_3.79) | 0.88 |
History of IV drug user | 2 (2.08%) | 1 (3.85%) | 1.18 (0.52_2.65) | 0.6 |
3-months exposure before candidemia | ||||
Blood/ Platelet transfusion | 60 (62.5%) | 20 (76.92%) | 1.14 (0.95_1.36) | 0.16 |
Recent hospital admission | 20 (20.83%) | 8 (30.77%) | 1.13 (0.87_1.45) | 0.28 |
Broad spectrum antibiotics | 90 (93.75%) | 26 (100%) | 1.28 (1.16_1.42) | 0.19 |
Polyene antifungal | 3 (3.13) | 0 | 0.78 (0.71_0.85) | 0.36 |
Azole antifungal (fluconazole) | 8 (8.33%) | 1 (3.85%) | 0.87 (0.68_1.12) | 0.43 |
Echinocandins | 19 (19.79%) | 12 (46.15%) | 1.38 (1.02_1.85) | 0.006 |
Corticosteroids | 52 (54.17%) | 19 (73.08%) | 1.17 (0.98_1.4) | 0.08 |
TPN | 13 (13.54%) | 4 (15.38%) | 1.03 (0.78_1.36) | 0.81 |
Central catheter insertion | 71 (73.96%) | 21 (80.77%) | 1.07 (0.88_1.31) | 0.47 |
Urine catheter | 73 (76.04%) | 17 (65.38%) | 0.88 (0.69_1.12) | 0.27 |
Invasive Ventilation | 44 (45.83%) | 20 (76.92%) | 1.3 (1.08_1.57) | 0.005 |
Previous surgery | 38 (39.58%) | 14 (53.85%) | 1.13 (0.93_1.37) | 0.19 |
GI | 21(55.26%) | 4 (28.5%) | 1.08 (0.88_1.31) | 0.42 |
Non- GI | 17 (44.7%) | 10 (71.4%) | ||
Renal Replacement therapy | 36 (37.5%) | 12 (46.15%) | 1.08 (0.88_1.31) | 0.42 |
HD | 26 (27.08) | 12 (46.15) | 1.21 (0.96_1.54) | 0.06 |
PD | 3 (3.13) | 0 | ||
CRRT | 9 (9.38) | 0 | ||
SLID | 2 (2.08) | 2 (7.69) | 1.59 (0.59–4.2) | 0.15 |