Enterococcal periprosthetic joint infection: clinical and microbiological findings from an 8-year retrospective cohort study

Table 4 Surgical and antimicrobial treatment of 75 patient with enterococcal PJI

	All episodes (n = 75)	Mono-microbial (n = 37)	Poly-microbial (n = 38)	P value
Surgical treatment
Prosthesis retention^a	13 (17)	7	6	0.768
One-stage exchange^b	10 (13)	5	5	1.000
Multi-stage exchange^c	43 (57)	20	23	0.644
No. surgical interventions needed, median (range)	2 (2–8)	2 (2–5)	3 (2–8)	0.039
Resection arthroplasty	9 (12)	5	4	0.736
Antimicrobial treatment^d
Intravenous antibiotic agent
Penicillin derivative	61/74 (82)	30/37 (81)	31/37 (84)	1.000
Vancomycin or daptomycin	12/74 (16)	6/37 (16)	6/37 (16)	1.000
Other	1/74 (3)	1/37 (3)	–
Additive agent for combination treatment
Fosfomycin	17/74 (23)	9/37 (24)	8/37 (22)	1.000
Gentamicin	16/74 (22)	11/37 (30)	5/37 (14)	0.157
Fosfomycin and gentamicin	8/74 (11)	5/37 (14)	3/37 (8)	0.711
Vancomycin or daptomycin	18/74 (24)	4/37 (11)	14/37 (38)	0.013
None	15/74 (20)	8/37 (22)	7/37 (20)	1.000
Median total duration (range) – weeks^d	16 (2–52)	15 (4–39)	16 (2–52)	0.459
Prolonged treatment duration (> 12 weeks)	35/74 (47)	17/37 (46)	18/37 (49)	1.000

Data are no. (%) of patients, unless otherwise indicated. Where the denominator is shown, data was not available for all patients
^aIncluding exchange of mobile parts (n = 7), debridement only (n = 4) and no surgery (n = 1)
^bIn 3 patients, only partial exchange was performed
^cMedian interval between explantation and re-implantation was 84 days (range, 29–292 days)
^dOne patient received no antimicrobial treatment

ISSN: 1471-2334