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Table 2 Capillary piperaquine concentration, stratified by treatment outcome and day

From: Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine

Day

Median (IQR) capillary piperaquine concentration (ng/mL)

Unadjusted treatment outcomes

Adjusted treatment outcomes

 

Treatment Success (n = 52)

Treatment Failure (n = 98)

p

Re-infection (n = 63)

Recrudescence (n = 35)

p

2

126 (61.4–215.0)

58.4 (30.3–105.0)

0.002

61.5 (34.3–105)

61.5 (35.8–94.3)

0.939

4

110.5 (77.5–155.5)

66.7 (32.4–103.0)

< 0.001

72.8 (38.8–106)

59.4 (24.3–98.9)

0.300

7

66.7 (41.8–81.9)

34.7 (17.9–49.1)

< 0.001

35.3 (17.9–55.2)

34.8 (18.1–45.1)

0.847

28

15.3 (11.3–23.6)

10.8 (7.6–14.3)

0.001

11.4 (7.3–16.7)

14.3 (8.2–18.1)

0.549

35

12.1 (8.2–5.6)

10.4 (5.0–15.4)

0.352

7.9 (4.9–11.1)

15.4 (13.2–22.2)

0.095