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Table 2 Adverse pregnancy outcomes associated with Q fever seropositivity in bivariate and multivariate analysis, among 179 pregnant women, Saint Pierre, Reunion island, May to October 2013

From: Pregnancy outcomes of Q fever: prospective follow-up study on Reunion island

Adverse pregnancy outcomes

n

%

P value

Crude IRR

95% CI

Adjusted IRRb

95% CI

A. Exposure variable: Coxiella burnetii Phase 2 IgG ≥ 1:64

 Composite outcomea

  

0.004

    

  In exposed

18 / 19

94.7

 

1.53

1.30–1.80

1.55

1.31–1.84

  In unexposed

99 / 160

61.9

 

1

 

1

 

 Miscarriage

  

0.004

    

  In exposed

10 / 19

52.6

 

2.34

1.39–3.92

2.33

1.48–3.67

  In unexposed

36 / 160

22.5

 

1

 

1

 

 Stillbirth

  

0.287

    

  In exposed

2 / 19

10.5

 

2.11

0.48–9.23

1.70

0.43–6.70

  In unexposed

8 / 160

5.0

 

1

 

1

 

 Preterm birth

  

0.568

    

  In exposed

5 / 19

26.3

 

1.24

0.55–2.79

1.38

0.72–2.62

  In unexposed

34 / 160

21.3

 

1

 

1

 

 Small-for-gestational age

 

0.959

    

  In exposed

5 / 19

26.3

 

0.98

0.44–2.17

1.03

0.49–2.13

  In unexposed

43 / 160

26.9

     

B. Exposure variable: Coxiella burnetii Phase 2 IgG ≥ 1:256 or Phase 2 IgM ≥ 1:48

 Composite outcomea

  

0.168

    

  In exposed

9 / 10

90.0

 

1.41

1.11–1.78

1.47

1.15–1.89

  In unexposed

108/169

63.9

 

1

 

1

 

 Miscarriage

  

0.070

    

  In exposed

5 / 10

50.0

 

2.06

1.04–4.05

1.78

0.94–3.39

  In unexposed

41 / 169

24.3

 

1

 

1

 

 Stillbirth

  

0.099

    

  In exposed

2 / 10

20.0

 

4.23

1.02–17.41

3.19

0.92–11.00

  In unexposed

8 / 169

4.7

 

1

 

1

 

 Preterm birth

  

0.456

    

  In exposed

3 / 10

30.0

 

1.41

0.52–3.80

1.75

0.71–4.31

  In unexposed

36 / 169

21.3

 

1

 

1

 

 Small-for-gestational age

 

0.292

    

  In exposed

1 / 10

10.0

 

0.35

0.05–2.36

0.42

0.06–2.87

  In unexposed

47/169

27.8

 

1

   
  1. Data are numbers, seropositive rates (%), crude and adjusted incidence rate ratios (IRR) and 95% confidence intervals (95% CI). P values are given for Pearson chi2 tests. aMiscarriage, stillbirth, or preterm birth, or small-for-gestational age. bMultivariate Poisson regression model with robust variance option adjusted on hypertensive pregnancy disorders, diabetes (gestational or pregestational), and maternal addictions (smoking or alcohol)