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Table 1 Clinical characteristics of index cases and household members for EV infection by RT-PCR and neutralizing antibodies

From: Transmission and serotype features of hand foot mouth disease in household contacts in Dong Thap, Vietnam

Characteristics RT-PCR (+) RT-PCR (−) Neutralizing antibodies# (+) Neutralizing antibodies# (−)
INDEX CASES 90 (60) 60 (40) 101 (71) ¥ 41 (29)
Symptoms
 Hand blisters 64 (72) 25 (28) 67 (80) 17 (20)
 Foot blisters 58 (73) 22 (28) 60 (81) 14 (19)
 Knee blisters 7 (58) 5 (42) 9 (82) 2 (18)
 Buttocks blisters 1 (33) 2 (67) 2 (67) 1 (33)
 Mouth sores 77 (60) 51 (40) 88 (73) 33 (27)
 Fever 89 (61) 58 (39) 100 (71) 40 (29)
 Startle 76 (63) 44 (37) 80 (70) 34 (30)
 Erythema 58 (64) 32 (36) 68 (79) 18 (21)
 Fatigue 1 (100) 0 (0) 1 (100) 0 (0)
 Vomiting 2 (40) 3 (60) 1 (25) 3 (75)
 Diarrhea 2 (50) 2 (50) 1(25) 3 (75)
 Anorexia 6 (100) 0 (0) 5 (100) 0 (0)
Severity *
 1 4 (80) 1 (20) 5 (100) 0 (0)
 2a 84 (62) 52 (38) 94 (73) 34 (27)
 2b 1 (25) 3 (75) 1 (25) 3 (75)
 3 1 (100) 0 (0) 0 (0) 1 (100)
HOUSEHOLD CONTACTS 12 (2) 569 (98) 142 (26) 403 (74)
Symptoms
 Illness 0 (0) 28 (100) 6 (21) 22 (79)
 Fever 0 (0) 11 (100) 2 (18) 9 (82)
 HFMD 0 (0) 4 (100) 0 (0) 4 (100)
 Rash 0 (0) 1 (100) 0 (0) 1 (100)
  1. Values expressed as number (percentage) unless otherwise indicated
  2. * Defined according to Viet Nam Ministry of Health guidelines
  3. # Defined as 4-fold change in a single EV71, CA6, CA16 (or more) serotype neutralizing antibody titers between sample 1 and sample 2
  4. Experienced illness in the past 2 weeks; Fever: experienced fever in the past 2 weeks; HFMD: experienced Hand, Foot and Mouth disease in the past 4 weeks; Rash: exhibited a sore on hand, foot or mouth in the past 4 weeks
  5. ¥ 8 index cases did not agree to collect the sample 2 (total 142 samples)
  6. 36 household contacts did not agree to collect the sample 2 (total 545 samples)
  7. Missing data due to missing samples for neutralizing antibodies testing and incomplete questionnaires, denominator values across table vary, percentages are representative of data available