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Table 1 Demographic and clinical characteristics of the study population

From: Clinical prediction and diagnosis of neurosyphilis in HIV-negative patients: a case-control study

CharacteristicsTotal (n = 100)
Median (IQR)/N (%)
Non-NS group (n = 50)
Median (IQR)/N (%)
NS group (n = 50)
Median (IQR)/N (%)
p value
Age, years47(40–52)47(40–52)47(40–54)0.953
Gender   0.106
 Female25 (25.0%)16(32.0%)9(18.0%) 
 Male75 (75.0%)34(68.0%)41(82.0%) 
Domicile place   0.585
 Guangdong Province84 (84.0%)41(82.0%)43(86.0%) 
 Other provinces16 (16.0%)9(18.0%)7(14.0%) 
Marital status   0.025
 Single11 (11.0%)9(18.0%)2(4.0%) 
 Married89 (89.0%)41(82.0%)48(96.0%) 
Occupation   0.418
 Permanent job58 (58.0%)31(62.0%)27(54.0%) 
 Temporary job42 (42.0%)19(38.0%)23(46.0%) 
Neurological symptoms28 (28.3%)5(10.2%)23(46.0%)< 0.001
Serum TRUST titer1:8 (1:4–1:16)1:4 (1:2–1:16)1:16(1:8–1:32)< 0.001
Serum TPPA titer1:1280 (> 1:1280–1:1280)1:1280 (1:1280–1:1280)> 1:1280 (> 1:1280–1:1280)0.006
Serum TP-IgM31(41.9%)9(27.3%)22(53.7%)0.022
CSF TRUST titerNeg (Neg- Neg)Neg (Neg- Neg)1:2 (Neg-1:4)< 0.001
CSF TPPA titer1:640 (Neg-1:1280)Neg (Neg-1:160)1:1280 (1:1280–1:1280)< 0.001
CSF protein, mg/L365.0 (270.0–598.9)377.6(237.0–421.2)521.5 (300.5–796.0)< 0.001
CSF WBC, cells/μL1 (0–5)0(0–5)3(0–10)0.005
CSF glucose, mmol/L3.61 (3.30–4.00)3.70 (3.35–4.00)3.5(3.2–3.9)0.036
CSF chlorides, mmol/L120.0 (117.0–122.0)121.0(117.8–124.5)118.1(115.8–122.0)0.009
  1. NS Neurosyphilis, TRUST Toludine red unheated serum test, TPPA Treponema pallidum particle agglutination, TP-IgM Treponema pallidum IgM, CSF Cerebrospinal fluid, Neg Negative, WBC White blood cell. Median and interquartile range (IQR) were used to describe continuous variables, while frequencies and percentages were used to describe categorical variables