Table 2 Cox univariate analysis of one-year mortality in patients ≥65 year old with infective endocarditis

 Male

35 (74.5)

6 (50.0)

.267

 Length of hospital stay

25 ± 21

16 ± 10

.052

 Symptoms before echocardiography

26 ± 37

16 ± 17

.355

 Duration of symptoms

before diagnosis, median (IQR),days

24.0 (12.0–42.0)

29.0 (10.3–54.8)

.799

 Time interval from emboli to diagnosis

12 ± 10

11 ± 11

.868

 Time interval from cerebral emboli to diagnosis

15 ± 13

12 ± 12

.724

 Native valve

40 (85.1)

9 (75.0)

.518

 Prosthetic valve

6 (12.8)

2 (16.7)

.862

 Community origin

42 (89.4)

5 (41.7)

P<0.001

 Nosocomial origin

2 (4.3)

4 (33.3)

P<0.001

 With predisposing cardiac disease

29 (61.7)

6 (50.0)

.457

 Rheumatic heart disease

8 (17.0)

3 (25.0)

.752

 Congenital heart disease

9 (19.1)

1 (8.3)

.482

 Previous cardiac surgery

10 (21.3)

4 (33.3)

.475

 Degenerative heart disease

6 (12.8)

0

.466

 Chronic pulmonary disease

1 (2.1)

1 (8.3)

.343

 Cancer

2 (4.3)

0

.690

 Hemodialysis

1 (2.1)

3 (25.0)

.007

 Liver cirrhosis

.713

 Hypertension

18 (38.3)

7 (58.3)

.272

 Diabetes

7 (14.9)

3 (25.0)

.565

 Immunodepression

0

4 (33.3)

P<0.001

 Bad oral hygiene

22 (46.8)

7 (58.3)

.713

 Anemia

31 (66.0)

7 (58.3)

.425

 Fever

44 (93.6)

9 (75.0)

.046

 Splenomegaly

11 (23.4)

2 (16.7)

.491

 Hepatomegaly

1 (2.1)

1 (8.3)

.516

 New or changing heart murmur

39 (83.0)

6 (50.0)

.021

 Heart failure

25 (53.2)

12 (100.0)

.106

 Total emboli

16 (34.0)

7 (58.3)

.143

 Emboli under treatment

8 (17.0)

4 (33.3)

.295

 Intracranial infection

1 (2.1)

0

.713

 Cerebral emboli

8 (17.0)

6 (50.0)

.053

 Cerebral hemorrhage

1 (2.1)

1 (8.3)

.404

 Arrhythmia

16 (34.0)

7 (58.3)

.202

 Renal insufficiency

9 (19.1)

9 (75.0)

.001

 Hepatic insufficiency

3 (6.4)

3 (25.0)

.092

 Pulmonary arterial hypertension

15 (31.9)

8 (66.7)

.037

 Moderate or severe valve regurgitation

10 (21.3)

2 (16.7)

.570

 Moderate or severe valve stenosis

4 (8.5)

1 (8.3)

.912

 Annular abscess

5 (10.6)

2 (16.7)

.564

 Pseudoaneurysm

1 (2.1)

1 (8.3)

.289

 Valvular perforation

10 (21.3)

3 (25.0)

.781

 Pitt score ≥ 4

1 (2.1)

5 (41.7)

.001

 Vegetation length

.062

≤10 mm

25 (53.2)

4 (33.3)

>10 mm<20 mm

19 (40.4)

5 (41.7)

≥20 mm ≤ 30 mm

3 (6.4)

1 (8.3)

>30 mm

0

2 (16.7)

.039

Microbiology

.050

 Streptococci

12 (48.0)

1 (16.7)

.268

 Staphylococci

8 (32.0)

3 (50.0)

.679

 Staphylococcus aureus

0

2 (33.3)

.039

 Enterococci

1 (4.0)

0

 Fungi

0

1 (16.7)

 Surgical treatment

23 (48.9)

1 (8.3)

.018