Table 4 MIC value of antibiotics (μg/ml) in absence and in presence of the efflux pump inhibitor (PAßN)
H. pylori clinical isolate | Antibiotics | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MET | CLR | ERY | AMP | AMO | DOX | |||||||||||||
A | P | F | A | P | F | A | P | F | A | P | F | A | P | F | A | P | F | |
HP | 128 | 4 | 31.2 | 16 | 0.25 | 15.2 | 8 | <0.2 | 31.2 | ≠| ≠| / | ≠| ≠| / | 2 | <0.2 | 125 |
HP002 | 128 | 4 | 31.2 | 2 | <0.2 | 125 | 2 | <0.2 | 125 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0094 | 128 | 8 | 62.5 | – | – | – | 4 | <0.2 | 62.5 | ≠| ≠| / | ≠| ≠| / | 2 | <0.2 | 125 |
HP0072 | 128 | 4 | 125 | – | – | – | 2 | 0.5 | 250 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0099 | 128 | 16 | 125 | – | – | – | 2 | 0.25 | 125 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0095 | 128 | 2 | 15.6 | 4 | <0.2 | 62.5 | 8 | 0.25 | 31.2 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP00115 | 128 | 8 | 62.5 | 1 | <0.2 | 250 | 2 | <0.2 | 125 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP00117 | 128 | 8 | 62.5 | 8 | <0.2 | 31.2 | 8 | 0.25 | 31.2 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP00105 | 128 | 4 | 31.2 | – | – | – | 8 | 0.25 | 31.2 | ≠| ≠| / | ≠| ≠| / | 1 | <0.2 | 250 |
HP0060 | 128 | 16 | 125 | – | – | – | 1 | 0.25 | 250 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0063 | 128 | 8 | 62.5 | – | – | – | 8 | <0.2 | 31.2 | ≠| ≠| / | – | – | – | – | – | – |
HP0050 | 128 | 8 | 62.5 | – | – | – | 4 | <0.2 | 62.5 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0048 | 128 | 16 | 125 | – | – | – | 4 | <0.2 | 62.5 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0069 | 128 | 4 | 31.2 | – | – | – | 2 | 0.5 | 125 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0070 | 128 | 4 | 31.2 | – | – | – | 4 | <0.2 | 62.5 | ≠| ≠| / | ≠| ≠| / | 0.5 | <0.2 | 500 |
HP0055 | 128 | 4 | 31.2 | – | – | – | 8 | 1 | 125 | ≠| ≠| / | ≠| ≠| / | 2 | <0.25 | 125 |
HP00102HD | 128 | 8 | 62.5 | – | – | – | 4 | 0.25 | 31.2 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP00132 | 128 | 16 | 125 | – | – | – | 1 | 0.25 | 250 | ≠| ≠| / | ≠| ≠| 1 | – | – | – |
HP00131 | ≠| 8 | 62.5 | – | – | – | 8 | 0.25 | 31.2 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP00133 | 128 | 16 | 125 | – | – | – | – |  |  | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0045HGD | 128 | 16 | 125 | – | – | – | 8 | <0.2 | 31.25 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0098HGD | 128 | 8 | 62.5 | – | – | – | – |  |  | ≠| ≠| / | ≠| ≠| 1 | – | – | – |
HP00100HD | 128 | 8 | 62.5 | – | – | – | 4 | 0.25 | 62.5 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0064 | ≠| 1 | 7.8 | – | – | – | 8 | <0.2 | 31.2 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0065 | 128 | 8 | 62.5 | – | – | – | – |  |  | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0066 | 128 | 16 | 125 | – | – | – | 8 | <0.2 | 31.2 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0063HGD | ≠| 8 | 62.5 | – | – | – | 4 | 0.25 | 62.5 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0044HGD | 128 | 16 | 125 | – | – | – | 4 | 0.25 | 62.5 | ≠| ≠| / | – | – |  | – | – | – |
HP0046HGD | 128 | 16 | 125 | – | – | – | 4 | 0.25 | 62.5 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0036 | 128 | 4 | 31.25 | – | – | – | 8 | 0.25 | 31.2 | ≠| ≠| / | ≠| ≠| / | – | – | – |
HP0061 | 128 | 16 | 125 | – | – | – | 8 | 0.5 | 62.5 | ≠| ≠| / | 128 | 128 | 1 | – | – | – |
HP0062 | ≠| 4 | 31.2 | – | – | – | 8 | 0.5 | 62.5 | ≠| ≠| / | ≠| ≠| / | – | – | – |
Activity spectrum (%) | 0 | 34.4 | Â | 0 | 100 | Â | 6.9 | 100 | Â | 0 | 0 | Â | 0 | 0 | Â | 40 | 100 | Â |