Table 1 Screening of antibiotics for anti-H. pylori activity using disc diffusion method
Antibiotics | Breakpoint | Mean zone diameter (mm) | Inhibition diameter range (mm) |
|---|---|---|---|
Amoxicillin (AMO) | ≥21 < 16 | 6.21 ± 1.35 | 6–12 |
Co-Amoxiclav (AMC) | ≥23 < 16 | 6.59 ± 3.02 | 6–28 |
Penicillin (PEN) | ≥23 < 16 | 6.125 ± 0.5 | 6–8 |
Imipenem (IMP) | ≥29 < 18 | 6.25 ± 0.61 | 6–8 |
Metronidazole (MET) | ≥24 < 17 | 22 ± 1.63 | 20–24 |
Clarithromycin (CLR) | ≥ND < 21 | 6.49 ± 2.43 | 6–22 |
Azithromycin (AZT) | ≥22 < 16 | 22.91 ± 4.25 | 10–30 |
Erythromycin (ERY) | ≥22 < 16 | 29.89 ± 6.25 | 18–40 |
Rifabutin (RIF) | ≥22 < 17 | 17.59 ± 6.58 | 6–30 |
Tetracycline (TET) | ND < 17 | 20.61 ± 1.93 | 18–32 |
Doxycycline (DOX) | ≥19 < 17 | 20.83 ± 3.11 | 12–30 |
Minocycline (MIN) | ≥19 < 17 | 22.55 ± 4.53 | 16–34 |
Levofloxacin (LEV) | ≥19 < 17 | 23.08 ± 2.29 | 18–28 |
Ciprofloxacin (CIP) | ≥25 < 20 | 31.40 ± 3.99 | 22–40 |
Norfloxacin (NOR) | ≥25 < 12 | 31.20 ± 3.42 | 20–40 |
Ampicillin (AMP) | ≥25 < 20 | 28.38 ± 2.27 | 22–32 |