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Table 2 Core mutations observed in Botswana sequences and their association with disease progression and/or therapeutic response

From: Molecular characterization of hepatitis C virus in liver disease patients in Botswana: a retrospective cross-sectional study

Mutation Genotype Mutation frequency Clinical relevance Reference
G95E 4v 1 Not characterized [16]
R9T 5a 4 Not characterized [17]
K10Q 5a 4 Increased risk of HCC [18]
T15I 5a 4 Not characterized [19, 20]
L36 V 5a 1 Not characterized [21]
R70Q 5a 4 Increased risk of HCC + poor response to IFN [17, 22, 23,24,25]
  1. Abbreviations: HCC Hepatocellular carcinoma, IFN Interferon