Molecular characterization of hepatitis C virus in liver disease patients in Botswana: a retrospective cross-sectional study

Table 2 Core mutations observed in Botswana sequences and their association with disease progression and/or therapeutic response

Mutation	Genotype	Mutation frequency	Clinical relevance	Reference
G95E	4v	1	Not characterized	[16]
R9T	5a	4	Not characterized	[17]
K10Q	5a	4	Increased risk of HCC	[18]
T15I	5a	4	Not characterized	[19, 20]
L36 V	5a	1	Not characterized	[21]
R70Q	5a	4	Increased risk of HCC + poor response to IFN	[17, 22, 23,24,25]

ISSN: 1471-2334