CD40 polymorphisms were associated with HCV infection susceptibility among Chinese population

BMC Infectious Diseases

Table 2 Genotypes distributions of TNFRSF5 SNPs among control, spontaneous clearance and persistent infection groups

SNPs (genotype)	Group A	Group B	Group C	Group (B + C)/Group A		Group C/Group B
SNPs (genotype)	n(%)	n(%)	n(%)	OR(95%CI)^a	P ^a	OR(95%CI)^b	P ^b
rs1535045
CC	688 (46.5)	214 (43.9)	328 (43.6)	1.00	–	1.00	–
CT	648 (43.8)	211 (43.3)	322 (42.8)	1.043 (0.884-1.231)	0.618	0.979 (0.763-1.256)	0.867
TT	142 (9.7)	62 (12.8)	103 (13.6)	1.397 (1.078-1.809)	0.011	1.095 (0.760-1.576)	0.626
Dominant model				1.109 (0.948-1.297)	0.197	1.005 (0.796-1.271)	0.964
Additive model				1.135 (1.011-1.275)	0.032	1.027 (0.869-1.215)	0.752
Recessive model				1.368 (1.070-1.749)	0.012	1.106 (0.785-1.559)	0.564
rs1883832
CC	567 (39.4)	178 (37.3)	275 (37.7)	1.00	–	1.00	–
CT	693 (48.2)	217 (45.5)	333 (45.6)	1.019 (0.858-1.210)	0.833	1.008 (0.778-1.306)	0.951
TT	178 (12.4)	82 (17.2)	122 (16.7)	1.351 (1.060-1.722)	0.015	0.980 (0.695-1.383)	0.909
Dominant model				1.090 (0.926-1.282)	0.300	1.001 (0.785-1.275)	0.997
Additive model				1.127 (1.004-1.263)	0.042	0.993 (0.841-1.173)	0.937
Recessive model				1.337 (1.069-1.673)	0.011	0.976 (0.713-1.335)	0.878
rs4810485
GG	604 (40.6)	190 (39.7)	306 (41.0)	1.00	–	1.00	–
GT	693 (46.6)	211 (44.1)	328 (43.9)	0.970 (0.819-1.148)	0.721	0.981 (0.761-1.266)	0.885
TT	191 (12.8)	78 (16.2)	113 (15.1)	1.201 (0.944-1.527)	0.136	0.927 (0.655-1.312)	0.667
Dominant model				1.021 (0.871-1.196)	0.802	0.967 (0.762-1.227)	0.780
Additive model				1.063 (0.949-1.190)	0.290	0.967 (0.819-1.141)	0.688
Recessive model				1.220 (0.976-1.526)	0.081	0.936 (0.679-1.290)	0.685

Abbreviations: CI confidence interval, HCV hepatitis C virus, OR odds ratio, SNP single nucleotide polymorphism
Group A: controls; Group B: spontaneous clearance subjects; Group C: persistent infection patients. Group (B + C): Infected individuals
^aThe P value, OR and 95% CIs of Group (B + C) versus Group A were calculated on the basis of the logistic regression model, adjusted by gender, age and routes of infection
^bThe P value, OR and 95% CIs of Group C versus Group B were calculated on the basis of the logistic regression model, adjusted by gender, age and routes of infection
Bonferroni correction was applied and the P value was adjusted to 0.0167 (0.05/3)
Bold type indicates statistically significant results

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