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Table 2 Genotypes distributions of TNFRSF5 SNPs among control, spontaneous clearance and persistent infection groups

From: CD40 polymorphisms were associated with HCV infection susceptibility among Chinese population

SNPs (genotype) Group A Group B Group C Group (B + C)/Group A Group C/Group B
n(%) n(%) n(%) OR(95%CI)a P a OR(95%CI)b P b
rs1535045
 CC 688 (46.5) 214 (43.9) 328 (43.6) 1.00 1.00
 CT 648 (43.8) 211 (43.3) 322 (42.8) 1.043 (0.884-1.231) 0.618 0.979 (0.763-1.256) 0.867
 TT 142 (9.7) 62 (12.8) 103 (13.6) 1.397 (1.078-1.809) 0.011 1.095 (0.760-1.576) 0.626
Dominant model     1.109 (0.948-1.297) 0.197 1.005 (0.796-1.271) 0.964
Additive model     1.135 (1.011-1.275) 0.032 1.027 (0.869-1.215) 0.752
Recessive model     1.368 (1.070-1.749) 0.012 1.106 (0.785-1.559) 0.564
rs1883832
 CC 567 (39.4) 178 (37.3) 275 (37.7) 1.00 1.00
 CT 693 (48.2) 217 (45.5) 333 (45.6) 1.019 (0.858-1.210) 0.833 1.008 (0.778-1.306) 0.951
 TT 178 (12.4) 82 (17.2) 122 (16.7) 1.351 (1.060-1.722) 0.015 0.980 (0.695-1.383) 0.909
Dominant model     1.090 (0.926-1.282) 0.300 1.001 (0.785-1.275) 0.997
Additive model     1.127 (1.004-1.263) 0.042 0.993 (0.841-1.173) 0.937
Recessive model     1.337 (1.069-1.673) 0.011 0.976 (0.713-1.335) 0.878
rs4810485
 GG 604 (40.6) 190 (39.7) 306 (41.0) 1.00 1.00
 GT 693 (46.6) 211 (44.1) 328 (43.9) 0.970 (0.819-1.148) 0.721 0.981 (0.761-1.266) 0.885
 TT 191 (12.8) 78 (16.2) 113 (15.1) 1.201 (0.944-1.527) 0.136 0.927 (0.655-1.312) 0.667
Dominant model     1.021 (0.871-1.196) 0.802 0.967 (0.762-1.227) 0.780
Additive model     1.063 (0.949-1.190) 0.290 0.967 (0.819-1.141) 0.688
Recessive model     1.220 (0.976-1.526) 0.081 0.936 (0.679-1.290) 0.685
  1. Abbreviations: CI confidence interval, HCV hepatitis C virus, OR odds ratio, SNP single nucleotide polymorphism
  2. Group A: controls; Group B: spontaneous clearance subjects; Group C: persistent infection patients. Group (B + C): Infected individuals
  3. aThe P value, OR and 95% CIs of Group (B + C) versus Group A were calculated on the basis of the logistic regression model, adjusted by gender, age and routes of infection
  4. bThe P value, OR and 95% CIs of Group C versus Group B were calculated on the basis of the logistic regression model, adjusted by gender, age and routes of infection
  5. Bonferroni correction was applied and the P value was adjusted to 0.0167 (0.05/3)
  6. Bold type indicates statistically significant results